ID   VACO 8
AC   CVCL_5411
SY   Vaco 8; VACO8; Vaco8; V8
DR   cancercelllines; CVCL_5411
DR   IARC_TP53; 9384
DR   Wikidata; Q54992812
RX   PubMed=6498841;
RX   PubMed=7761852;
RX   PubMed=8385345;
RX   PubMed=8755562;
RX   PubMed=9715273;
RX   PubMed=11314036;
CC   Doubling time: 46 hours (PubMed=6498841).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro190Leu (c.569C>T); ClinVar=VCV000418517; Zygosity=Hemizygous (PubMed=9715273).
CC   Derived from site: In situ; Cecum; UBERON=UBERON_0001153.
DI   NCIt; C5543; Cecum adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 19
//
RX   PubMed=6498841;
RA   McBain J.A., Weese J.L., Meisner L.F., Wolberg W.H., Willson J.K.V.;
RT   "Establishment and characterization of human colorectal cancer cell
RT   lines.";
RL   Cancer Res. 44:5813-5821(1984).
//
RX   PubMed=7761852; DOI=10.1126/science.7761852;
RA   Markowitz S.D., Wang J., Myeroff L.L., Parsons R., Sun L.-Z.,
RA   Lutterbaugh J.D., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B.,
RA   Brattain M.G., Willson J.K.V.;
RT   "Inactivation of the type II TGF-beta receptor in colon cancer cells
RT   with microsatellite instability.";
RL   Science 268:1336-1338(1995).
//
RX   PubMed=8385345; DOI=10.1073/pnas.90.7.2846; PMCID=PMC46193;
RA   Smith K.J., Johnson K.A., Bryan T.M., Hill D.E., Markowitz S.D.,
RA   Willson J.K.V., Paraskeva C., Petersen G.M., Hamilton S.R.,
RA   Vogelstein B., Kinzler K.W.;
RT   "The APC gene product in normal and tumor cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2846-2850(1993).
//
RX   PubMed=8755562; DOI=10.1073/pnas.93.15.7832; PMCID=PMC38834;
RA   Liu D.-C., Pearlman E., Diaconu E., Guo K., Mori H., Haqqi T.,
RA   Markowitz S.D., Willson J.K.V., Sy M.-S.;
RT   "Expression of hyaluronidase by tumor cells induces angiogenesis in
RT   vivo.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:7832-7837(1996).
//
RX   PubMed=9715273; DOI=10.1038/sj.onc.1201986;
RA   Eshleman J.R., Casey G., Kochera M.E., Sedwick W.D., Swinler S.E.,
RA   Veigl M.L., Willson J.K.V., Schwartz S., Markowitz S.D.;
RT   "Chromosome number and structure both are markedly stable in RER
RT   colorectal cancers and are not destabilized by mutation of p53.";
RL   Oncogene 17:719-725(1998).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L.,
RA   Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R.,
RA   Minna J.D.;
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//