ID   VACO 6
AC   CVCL_5410
SY   Vaco 6; VACO6; Vaco6; V6
DR   cancercelllines; CVCL_5410
DR   Cosmic; 1090613
DR   Cosmic; 2667981
DR   GEO; GSM1448220
DR   Wikidata; Q54992779
RX   PubMed=6498841;
RX   PubMed=7761852;
RX   PubMed=8385345;
RX   PubMed=8755562;
RX   PubMed=9515795;
RX   PubMed=9715273;
RX   PubMed=11314036;
RX   PubMed=12615714;
RX   PubMed=25926053;
CC   Doubling time: 26 hours (PubMed=6498841).
CC   Microsatellite instability: Instable (MSI) (PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (PubMed=12615714).
CC   Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (PubMed=12615714).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=9715273).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Cecum; UBERON=UBERON_0001153.
ST   Source(s): PubMed=25926053
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 11,14
ST   D16S539: 10,12,13
ST   D21S11: 29,31.2
ST   D5S818: 11
ST   D7S820: 7,10
ST   TH01: 9,9.3
ST   TPOX: 8,10
ST   vWA: 18,20,22
DI   NCIt; C5543; Cecum adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 22
//
RX   PubMed=6498841;
RA   McBain J.A., Weese J.L., Meisner L.F., Wolberg W.H., Willson J.K.V.;
RT   "Establishment and characterization of human colorectal cancer cell
RT   lines.";
RL   Cancer Res. 44:5813-5821(1984).
//
RX   PubMed=7761852; DOI=10.1126/science.7761852;
RA   Markowitz S.D., Wang J., Myeroff L.L., Parsons R., Sun L.-Z.,
RA   Lutterbaugh J.D., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B.,
RA   Brattain M.G., Willson J.K.V.;
RT   "Inactivation of the type II TGF-beta receptor in colon cancer cells
RT   with microsatellite instability.";
RL   Science 268:1336-1338(1995).
//
RX   PubMed=8385345; DOI=10.1073/pnas.90.7.2846; PMCID=PMC46193;
RA   Smith K.J., Johnson K.A., Bryan T.M., Hill D.E., Markowitz S.D.,
RA   Willson J.K.V., Paraskeva C., Petersen G.M., Hamilton S.R.,
RA   Vogelstein B., Kinzler K.W.;
RT   "The APC gene product in normal and tumor cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2846-2850(1993).
//
RX   PubMed=8755562; DOI=10.1073/pnas.93.15.7832; PMCID=PMC38834;
RA   Liu D.-C., Pearlman E., Diaconu E., Guo K., Mori H., Haqqi T.,
RA   Markowitz S.D., Willson J.K.V., Sy M.-S.;
RT   "Expression of hyaluronidase by tumor cells induces angiogenesis in
RT   vivo.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:7832-7837(1996).
//
RX   PubMed=9515795;
RA   Sparks A.B., Morin P.J., Vogelstein B., Kinzler K.W.;
RT   "Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal
RT   cancer.";
RL   Cancer Res. 58:1130-1134(1998).
//
RX   PubMed=9715273; DOI=10.1038/sj.onc.1201986;
RA   Eshleman J.R., Casey G., Kochera M.E., Sedwick W.D., Swinler S.E.,
RA   Veigl M.L., Willson J.K.V., Schwartz S., Markowitz S.D.;
RT   "Chromosome number and structure both are markedly stable in RER
RT   colorectal cancers and are not destabilized by mutation of p53.";
RL   Oncogene 17:719-725(1998).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L.,
RA   Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R.,
RA   Minna J.D.;
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//
RX   PubMed=12615714;
RA   Hempen P.M., Zhang L., Bansal R.K., Iacobuzio-Donahue C.A.,
RA   Murphy K.M., Maitra A., Vogelstein B., Whitehead R.H., Markowitz S.D.,
RA   Willson J.K.V., Yeo C.J., Hruban R.H., Kern S.E.;
RT   "Evidence of selection for clones having genetic inactivation of the
RT   activin A type II receptor (ACVR2) gene in gastrointestinal cancers.";
RL   Cancer Res. 63:994-999(2003).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//