ID   VACO 4S
AC   CVCL_5406
SY   VACO-4S; VACO4S; Vaco4S
DR   cancercelllines; CVCL_5406
DR   ColonAtlas; VACO4S
DR   Cosmic; 948849
DR   Cosmic; 986023
DR   Cosmic; 1043834
DR   Cosmic; 2302024
DR   Cosmic; 2760188
DR   GEO; GSM1346860
DR   GEO; GSM1374982
DR   Wikidata; Q54992767
RX   PubMed=6498841;
RX   PubMed=20606684;
RX   PubMed=23272949;
RX   PubMed=24755471;
CC   Part of: AstraZeneca Colorectal cell line (AZCL) panel.
CC   Doubling time: 30 hours (PubMed=6498841).
CC   Microsatellite instability: Stable (MSS) (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Ser1355fs*18 (c.4062_4066delTTCTT); Zygosity=Unspecified (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Trp524Cys (c.1572G>T); ClinVar=VCV002147050; Zygosity=Unspecified (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Asn239fs*1 (c.715_717AAC>T); Zygosity=Unspecified (PubMed=24755471).
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
DI   NCIt; C9383; Rectal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5405 ! VACO 4A
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
//
RX   PubMed=6498841;
RA   McBain J.A., Weese J.L., Meisner L.F., Wolberg W.H., Willson J.K.V.;
RT   "Establishment and characterization of human colorectal cancer cell
RT   lines.";
RL   Cancer Res. 44:5813-5821(1984).
//
RX   PubMed=20606684; DOI=10.1038/sj.bjc.6605780;
RA   Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.;
RT   "5-fluorouracil response in a large panel of colorectal cancer cell
RT   lines is associated with mismatch repair deficiency.";
RL   Br. J. Cancer 103:340-346(2010).
//
RX   PubMed=23272949; DOI=10.1186/1755-8794-5-66;
RA   Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A.,
RA   Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A.,
RA   Orphanides G., French T., Wessels L.F.A.;
RT   "Subtypes of primary colorectal tumors correlate with response to
RT   targeted treatment in colorectal cell lines.";
RL   BMC Med. Genomics 5:66.1-66.15(2012).
//
RX   PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013;
RA   Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S.,
RA   Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S.,
RA   O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F.,
RA   Mariadason J.M., Sieber O.M.;
RT   "Colorectal cancer cell lines are representative models of the main
RT   molecular subtypes of primary cancer.";
RL   Cancer Res. 74:3238-3247(2014).
//