ID   MGC-803
AC   CVCL_5334
SY   MGC803; MGc80-3
DR   BTO; BTO:0004953
DR   EFO; EFO_0006286
DR   ChEMBL-Cells; CHEMBL3706567
DR   ChEMBL-Targets; CHEMBL3706566
DR   Cosmic; 2267321
DR   GEO; GSM844588
DR   GEO; GSM1374671
DR   IARC_TP53; 24858
DR   PubChem_Cell_line; CVCL_5334
DR   Ubigene; YC-C081
DR   Wikidata; Q54905425
RX   CelloPub=CLPUB00751;
RX   DOI=10.1007/BF02948354;
RX   PubMed=24743803;
RX   PubMed=28107433;
RX   PubMed=28851942;
RX   PubMed=29683800;
RX   PubMed=29717028;
RX   PubMed=37543987;
CC   Problematic cell line: Contaminated. Seems to be an hybrid of HeLa and probably of a gastric cancer cell. The STR profile is highly similar to that of HeLa yet shows some specific differences that suggest it is an hybrid cell line (PubMed=37543987). Was originally thought to originate from a 53 year old male patient suffering from a poorly differentiated gastric mucinous adenocarcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00588.
CC   Doubling time: ~25 hours (CelloPub=CLPUB00751); 22.5 hours (PubMed=29683800).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Secretome proteome analysis by 2D-DE/MS.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Miscellaneous: Formerly the CCRID database had 2 entries describing this cell line (3111C0001CCC000227, 3131C0001000700084). They were one of the sources for the STR profile of this entry.
CC   Misspelling: BGC-803; Note=Occasionally.
CC   Misspelling: BGC803; Note=Occasionally.
CC   Misspelling: MCG803; GEO=GSM844588.
ST   Source(s): CCRID; PubMed=28107433; PubMed=28851942; PubMed=37543987
ST   Amelogenin: X
ST   CSF1PO: 9,10,12
ST   D10S1248: 15
ST   D12S391: 17,20,26
ST   D13S317: 7,13.3
ST   D16S539: 9,11
ST   D18S51: 13
ST   D19S433: 13
ST   D1S1656: 12,15,16
ST   D21S11: 27,28
ST   D22S1045: 15,17
ST   D2S1338: 17,24
ST   D2S441: 10,11
ST   D3S1358: 15,18
ST   D5S818: 10,11,12
ST   D6S1043: 18,19
ST   D7S820: 11,12
ST   D8S1179: 12,14
ST   FGA: 18,21
ST   Penta D: 8,15
ST   Penta E: 7,10,16,17
ST   TH01: 7,9
ST   TPOX: 12
ST   vWA: 16,17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
CA   Hybrid cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 28
RX   CelloPub=CLPUB00751;
RA   Wang K.-H.;
RT   "A in vitro cell (MGc80-3) of a poorly differentiated mucoid
RT   adenocarcinoma of human stomach.";
RL   Shi Yan Sheng Wu Xue Bao 16:257-266(1983).
RX   DOI=10.1007/BF02948354;
RA   Xiao H., Dong Z.-W., Shou C.-C.;
RT   "Induction of apoptosis in human gastric carcinoma cell line MGC-803
RT   by monoclonal antibody PD4.";
RL   Chin. J. Cancer Res. 10:169-173(1998).
RX   PubMed=24743803;
RA   Huang H., Han Y., Wu J., Tian Z.-H., Qu L.-K., Shou C.-C.;
RT   "Establishment of drug resistant cell line of MGC-803 and analysis of
RT   differential secretome.";
RL   Beijing Da Xue Xue Bao Yi Xue Ban 46:183-189(2014).
RX   PubMed=28107433; DOI=10.1371/journal.pone.0170384;
RA   Huang Y.-Q., Liu Y.-H., Zheng C.-Y., Shen C.;
RT   "Investigation of cross-contamination and misidentification of 278
RT   widely used tumor cell lines.";
RL   PLoS ONE 12:E0170384-E0170384(2017).
RX   PubMed=28851942; DOI=10.1038/s41598-017-09660-w;
RA   Bian X.-C., Yang Z.-L., Feng H.-L., Sun H., Liu Y.-Q.;
RT   "A combination of species identification and STR profiling identifies
RT   cross-contaminated cells from 482 human tumor cell lines.";
RL   Sci. Rep. 7:9774-9774(2017).
RX   PubMed=29683800; DOI=10.1097/CAD.0000000000000601;
RA   Fu L., Yin F., Li X.-R., Han B.-K., Zhang C., Wang J.-W., Wang Y.-Q.,
RA   Bi Y.-F., Liu H.-M.;
RT   "Generation and characterization of a paclitaxel-resistant human
RT   gastric carcinoma cell line.";
RL   Anticancer Drugs 29:491-502(2018).
RX   PubMed=29717028; DOI=10.1042/BSR20180277;
RA   Zhang Y.-Q., Yu S.-T., Zhang Z.-Z., Zhao G., Xu J.;
RT   "Long non-coding RNA AK096174 promotes cell proliferation and invasion
RT   in gastric cancer by regulating WDR66 expression.";
RL   Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018).
RX   PubMed=37543987; DOI=10.1002/ijc.34677;
RA   Cao F., Sun H., Yang Z.-L., Bai Y.-H., Hu X., Hou Y.-H., Bian X.-C.,
RA   Liu Y.-Q.;
RT   "Multiple approaches revealed MGc80-3 as a somatic hybrid with HeLa
RT   cells rather than a gastric cancer cell line.";
RL   Int. J. Cancer 154:155-168(2023).