Cellosaurus cell line MC4000 (CVCL

Cellosaurus MC4000 (CVCL_5331)

Cross-references
Cell line name	MC4000
Synonyms	MC-4000
Accession	CVCL_5331
Resource Identification Initiative	To cite this cell line use: MC4000 (RRID:CVCL_5331)
Comments	Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a breast carcinoma. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00143. Population: African American. Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease	Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0030 (HeLa)
Sex of cell	Female
Age at sampling	30Y6M
Category	Cancer cell line
Web pages	https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications	PubMed=9150904; DOI=10.1023/A:1005756632293 Hambly R.J., Double J.A., Thompson M.J., Bibby M.C. Establishment and characterisation of new cell lines from human breast tumours initially established as tumour xenografts in NMRI nude mice. Breast Cancer Res. Treat. 43:247-258(1997) PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2 MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G. Widespread intraspecies cross-contamination of human tumor cell lines arising at source. Int. J. Cancer 83:555-563(1999) PubMed=20143388; DOI=10.1002/ijc.25242 Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I. Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010)
Biological sample resources	BioSample; SAMN03151743
Encyclopedic resources	Wikidata; Q54904211
Entry history
Entry creation	04-Apr-2012
Last entry update	05-Oct-2023
Version number	21