ID   MaTu
AC   CVCL_5328
DR   BioSample; SAMN03151742
DR   Cosmic; 1523956
DR   Cosmic; 1523973
DR   Wikidata; Q54904065
RX   PubMed=212193;
RX   PubMed=9150904;
RX   PubMed=10508494;
RX   PubMed=10700188;
RX   PubMed=15677628;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a breast carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00142.
CC   Population: African American.
CC   Microsatellite instability: Stable (MSS) (PubMed=15677628).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; c.4790del138 (Ex20-21del); Zygosity=Heterozygous (PubMed=10700188).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; c.5061+2T>A; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=10700188).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 25
RX   PubMed=212193;
RA   Engel L.W., Young N.A.;
RT   "Human breast carcinoma cells in continuous culture: a review.";
RL   Cancer Res. 38:4327-4339(1978).
RX   PubMed=9150904; DOI=10.1023/A:1005756632293;
RA   Hambly R.J., Double J.A., Thompson M.J., Bibby M.C.;
RT   "Establishment and characterisation of new cell lines from human
RT   breast tumours initially established as tumour xenografts in NMRI nude
RT   mice.";
RL   Breast Cancer Res. Treat. 43:247-258(1997).
RX   PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2;
RA   MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H.,
RA   Drexler H.G.;
RT   "Widespread intraspecies cross-contamination of human tumor cell lines
RT   arising at source.";
RL   Int. J. Cancer 83:555-563(1999).
RX   PubMed=10700188; DOI=10.1038/73536;
RA   Gayther S.A., Batley S.J., Linger L., Bannister A.J., Thorpe K.,
RA   Chin S.-F., Daigo Y., Russell P., Wilson A., Sowter H.M.,
RA   Delhanty J.D.A., Ponder B.A.J., Kouzarides T., Caldas C.;
RT   "Mutations truncating the EP300 acetylase in human cancers.";
RL   Nat. Genet. 24:300-303(2000).
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C.,
RA   Edwards P.A.W., Caldas C.;
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).