ID   KPB-M15
AC   CVCL_5308
DR   BioSample; SAMN03151821
DR   cancercelllines; CVCL_5308
DR   Wikidata; Q54900427
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=3461189;
RX   PubMed=12592342;
RX   PubMed=20143388;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=KPB-M15
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a KYO-1 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the peripheral blood of a 39 year old male patient with chronic myelogenous leukemia, BCR-ABL1 positive.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00230.
CC   Population: Japanese.
CC   Doubling time: 24 hours (PubMed=3461189).
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2095 ! KYO-1
SX   Male
AG   22Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=3461189; DOI=10.1093/oxfordjournals.jjco.a039125;
RA   Kamamoto T., Ohkubo T., Sakoda H., Taniguchi Y., Kita K., Yoshida Y.,
RA   Uchino H.;
RT   "Establishment of two Ph1 chromosome-positive cell lines, KPB-M8 and
RT   KPB-M15.";
RL   Jpn. J. Clin. Oncol. 16:107-115(1986).
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.;
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//