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Cellosaurus KMT-2 (CVCL_5301)

[Text version]
Cell line name KMT-2
Accession CVCL_5301
Resource Identification Initiative To cite this cell line use: KMT-2 (RRID:CVCL_5301)
Comments Problematic cell line: Contaminated. Shown to be a KG-1 derivative (PubMed=16643607; PubMed=20143388). Originally thought to originate from umbilical cord blood cells.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00229.
Population: Caucasian.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 3688; FGFR1 + HGNC; 23098; FGFR1OP2; Name(s)=FGFR1OP2-FGFR1 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0374 (KG-1)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=KMT-2

PubMed=2198959; DOI=10.1182/blood.V76.3.501.501
Tamura S., Sugawara M., Tanaka H., Tezuka E., Nihira S.-i., Miyamoto C., Suda T., Ohta Y.
A new hematopoietic cell line, KMT-2, having human interleukin-3 receptors.
Blood 76:501-507(1990)

Tohyama K.
Human factor-dependent leukemia cell lines.
Int. J. Hematol. 65:309-317(1997)

PubMed=16643607; DOI=10.1111/j.1749-0774.2005.00007.x
Yoshino K., Iimura E., Saijo K., Iwase S., Fukami K., Ohno T., Obata Y., Nakamura Y.
Essential role for gene profiling analysis in the authentication of human cell lines.
Hum. Cell 19:43-48(2006)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line collections (Providers) RCB; RCB0712 - Discontinued
Cell line databases/resources cancercelllines; CVCL_5301
Biological sample resources BioSample; SAMN03151819
Encyclopedic resources Wikidata; Q54900194
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23