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Cellosaurus PMC42 (CVCL_5215)

[Text version]
Cell line name PMC42
Synonyms PMC-42; PMC 42; PMC42-ET; PMC-42 ET; PMC42ET
Accession CVCL_5215
Resource Identification Initiative To cite this cell line use: PMC42 (RRID:CVCL_5215)
Comments Part of: JWGray breast cancer cell line panel.
Population: Caucasian.
Doubling time: 2.3 days (PubMed=6572752).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5216 (PMC42-LA)
Sex of cell Female
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): PubMed=28889351

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,12
D7S8207,9
D13S31714
D16S5399,11
D21S1130,31.2
TH016
TPOX8,11
vWA15,19

Run an STR similarity search on this cell line
Web pages Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/pmc42.htm
Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

PubMed=6572752; DOI=10.1093/jnci/70.4.649
Robert H. Whitehead, Ivan Bertoncello, Lorna M. Webber, John S. Pedersen;
A new human breast carcinoma cell line (PMC42) with stem cell characteristics. I. Morphologic characterization.
J. Natl. Cancer Inst. 70:649-661(1983)

PubMed=6606728; DOI=10.1093/jnci/71.6.1193
Robert H. Whitehead, Paul Monaghan, Lorna M. Webber, Ivan Bertoncello, Angela A. Vitali;
A new human breast carcinoma cell line (PMC42) with stem cell characteristics. II. Characterization of cells growing as organoids.
J. Natl. Cancer Inst. 71:1193-1203(1983)

PubMed=6381852; DOI=10.1093/jnci/73.3.643
Robert H. Whitehead, Susan J. Quirk, Angela A. Vitali, John Watson Funder, Robert Lyndsay Sutherland, Leigh C. Murphy;
A new human breast carcinoma cell line (PMC42) with stem cell characteristics. III. Hormone receptor status and responsiveness.
J. Natl. Cancer Inst. 73:643-648(1984)

PubMed=2228321; DOI=10.1002/ijc.2910460531
Paul Monaghan, Michael G. Ormerod, Michael J. O'Hare;
Epidermal growth factor receptors and EGF-responsiveness of the human breast-carcinoma cell line PMC42.
Int. J. Cancer 46:935-943(1990)

DOI=10.1016/B978-0-12-333530-2.50009-5
Albert Leibovitz;
Cell lines from human breast.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.161-184; Academic Press; New York; USA (1994)

PubMed=11044355; DOI=10.1054/bjoc.2000.1458; PMCID=PMC2408781
Jeffrey M. Davidson, Kylie Louise Gorringe, Suet-Feung Chin, Beatrice Orsetti, C. Besret, Celine Courtay-Cahen, Ian Roberts, Charles Theillet, Carlos Caldas, Paul A.W. Edwards;
Molecular cytogenetic analysis of breast cancer cell lines.
Br. J. Cancer 83:1309-1317(2000)

PubMed=11161701; DOI=10.1006/excr.2000.5106
Margaret Leigh Ackland, Agnes Michalczyk, Robert H. Whitehead;
PMC42, a novel model for the differentiated human breast.
Exp. Cell Res. 263:14-22(2001)

DOI=10.25904/1912/1434
Brian J. Morrison;
Breast cancer stem cells: tumourspheres and implications for therapy.
Thesis PhD (2010); Griffith University; Brisbane; Australia

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Anneleen Daemen, Obi L. Griffith, Laura M. Heiser, Nicholas J. Wang, Oana M. Enache, Zachary Sanborn, Francois Pepin, Steffen Durinck, James E. Korkola, Malachi Griffith, Joe S. Hur ...Show all 27 authors... , Nam Huh, Jongsuk Chung, Leslie Cope, Mary Jo Fackler, Christopher Benedict Umbricht, Saraswati Sukumar, Pankaj Seth, Vikas P. Sukhatme, Lakshmi R. Jakkula, Yi-Ling Lu, Gordon B. Mills, Raymond J. Cho, Eric A. Collisson, Laura J. van 't Veer, Paul T. Spellman, Joe W. Gray; Show fewer authors
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Jodi M. Saunus, Chanel E. Smart, Jamie R. Kutasovic, Rebecca L. Johnston, Priyakshi Kalita-de Croft, Mariska Miranda, Esdy N. Rozali, Ana Cristina Vargas, Lynne E. Reid, Eva Lorsy, Sibylle Cocciardi ...Show all 23 authors... , Tatjana Seidens, Amy Ellen McCart Reed, Andrew J. Dalley, Leesa F. Wockner, Julie Johnson, Debina Sarkar, Marjan E. Askarian-Amiri, Peter T. Simpson, Kum Kum Khanna, Georgia Chenevix-Trench, Fares Al-Ejeh, Sunil R. Lakhani; Show fewer authors
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5215
Chemistry resources PharmacoDB; PMC42_1275_2019
Encyclopedic resources Wikidata; Q54947618
Gene expression databases GEO; GSM217595
GEO; GSM1172988
GEO; GSM3145572
GEO; GSM3145729
Polymorphism and mutation databases Progenetix; CVCL_5215
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number30