ID   Y-MESO-21
AC   CVCL_5180
DR   cancercelllines; CVCL_5180
DR   Cosmic; 2759221
DR   GEO; GSM552528
DR   GEO; GSM850288
DR   Progenetix; CVCL_5180
DR   Wikidata; Q54995140
RX   PubMed=19380521;
RX   PubMed=21245096;
RX   PubMed=22286761;
RX   PubMed=26011428;
CC   Population: Japanese.
CC   Sequence variation: Gene deletion; HGNC; HGNC:6515; LATS2; Zygosity=Homozygous (PubMed=21245096).
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C45662; Pleural epithelioid mesothelioma
DI   ORDO; Orphanet_50251; Pleural mesothelioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   66Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 16
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RX   PubMed=19380521; DOI=10.1093/carcin/bgp097;
RA   Kawaguchi K., Murakami H., Taniguchi T., Fujii M., Kawata S.,
RA   Fukui T., Kondo Y., Osada H., Usami N., Yokoi K., Ueda Y., Yatabe Y.,
RA   Ito M., Horio Y., Hida T., Sekido Y.;
RT   "Combined inhibition of MET and EGFR suppresses proliferation of
RT   malignant mesothelioma cells.";
RL   Carcinogenesis 30:1097-1105(2009).
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RX   PubMed=21245096; DOI=10.1158/0008-5472.CAN-10-2164;
RA   Murakami H., Mizuno T., Taniguchi T., Fujii M., Ishiguro F., Fukui T.,
RA   Akatsuka S., Horio Y., Hida T., Kondo Y., Toyokuni S., Osada H.,
RA   Sekido Y.;
RT   "LATS2 is a tumor suppressor gene of malignant mesothelioma.";
RL   Cancer Res. 71:873-883(2011).
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RX   PubMed=22286761; DOI=10.1038/onc.2012.5;
RA   Mizuno T., Murakami H., Fujii M., Ishiguro F., Tanaka I., Kondo Y.,
RA   Akatsuka S., Toyokuni S., Yokoi K., Osada H., Sekido Y.;
RT   "YAP induces malignant mesothelioma cell proliferation by upregulating
RT   transcription of cell cycle-promoting genes.";
RL   Oncogene 31:5117-5122(2012).
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RX   PubMed=26011428; DOI=10.1111/cas.12698; PMCID=PMC4556387;
RA   Hakiri S., Osada H., Ishiguro F., Murakami H., Murakami-Tonami Y.,
RA   Yokoi K., Sekido Y.;
RT   "Functional differences between wild-type and mutant-type
RT   BRCA1-associated protein 1 tumor suppressor against malignant
RT   mesothelioma cells.";
RL   Cancer Sci. 106:990-999(2015).
//