ID   Y-MESO-12
AC   CVCL_5178
DR   cancercelllines; CVCL_5178
DR   Cosmic; 2759216
DR   GEO; GSM552526
DR   GEO; GSM850303
DR   Progenetix; CVCL_5178
DR   RCB; RCB5667
DR   Wikidata; Q54995138
RX   PubMed=17270034;
RX   PubMed=19380521;
RX   PubMed=21245096;
RX   PubMed=22286761;
RX   PubMed=26011428;
RX   PubMed=28553954;
CC   Population: Japanese.
CC   Sequence variation: Gene deletion; HGNC; HGNC:7773; NF2; Zygosity=Homozygous (PubMed=21245096).
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by microarray.
CC   Donor information: No history of asbestos exposure (PubMed=17270034).
DI   NCIt; C45662; Pleural epithelioid mesothelioma
DI   ORDO; Orphanet_50251; Pleural mesothelioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   71Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 19
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RX   PubMed=17270034; DOI=10.1111/j.1349-7006.2006.00386.x; PMCID=PMC11158069;
RA   Taniguchi T., Karnan S., Fukui T., Yokoyama T., Tagawa H., Yokoi K.,
RA   Ueda Y., Mitsudomi T., Horio Y., Hida T., Yatabe Y., Seto M.,
RA   Sekido Y.;
RT   "Genomic profiling of malignant pleural mesothelioma with array-based
RT   comparative genomic hybridization shows frequent non-random
RT   chromosomal alteration regions including JUN amplification on 1p32.";
RL   Cancer Sci. 98:438-446(2007).
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RX   PubMed=19380521; DOI=10.1093/carcin/bgp097;
RA   Kawaguchi K., Murakami H., Taniguchi T., Fujii M., Kawata S.,
RA   Fukui T., Kondo Y., Osada H., Usami N., Yokoi K., Ueda Y., Yatabe Y.,
RA   Ito M., Horio Y., Hida T., Sekido Y.;
RT   "Combined inhibition of MET and EGFR suppresses proliferation of
RT   malignant mesothelioma cells.";
RL   Carcinogenesis 30:1097-1105(2009).
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RX   PubMed=21245096; DOI=10.1158/0008-5472.CAN-10-2164;
RA   Murakami H., Mizuno T., Taniguchi T., Fujii M., Ishiguro F., Fukui T.,
RA   Akatsuka S., Horio Y., Hida T., Kondo Y., Toyokuni S., Osada H.,
RA   Sekido Y.;
RT   "LATS2 is a tumor suppressor gene of malignant mesothelioma.";
RL   Cancer Res. 71:873-883(2011).
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RX   PubMed=22286761; DOI=10.1038/onc.2012.5;
RA   Mizuno T., Murakami H., Fujii M., Ishiguro F., Tanaka I., Kondo Y.,
RA   Akatsuka S., Toyokuni S., Yokoi K., Osada H., Sekido Y.;
RT   "YAP induces malignant mesothelioma cell proliferation by upregulating
RT   transcription of cell cycle-promoting genes.";
RL   Oncogene 31:5117-5122(2012).
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RX   PubMed=26011428; DOI=10.1111/cas.12698; PMCID=PMC4556387;
RA   Hakiri S., Osada H., Ishiguro F., Murakami H., Murakami-Tonami Y.,
RA   Yokoi K., Sekido Y.;
RT   "Functional differences between wild-type and mutant-type
RT   BRCA1-associated protein 1 tumor suppressor against malignant
RT   mesothelioma cells.";
RL   Cancer Sci. 106:990-999(2015).
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RX   PubMed=28553954; DOI=10.1038/onc.2017.147;
RA   Kato T., Sato T., Yokoi K., Sekido Y.;
RT   "E-cadherin expression is correlated with focal adhesion kinase
RT   inhibitor resistance in merlin-negative malignant mesothelioma
RT   cells.";
RL   Oncogene 36:5522-5531(2017).
//