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Cellosaurus SNU-685 (CVCL_5083)

[Text version]
Cell line name SNU-685
Synonyms SNU685; NCI-SNU-685
Accession CVCL_5083
Resource Identification Initiative To cite this cell line use: SNU-685 (RRID:CVCL_5083)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 20 hours (PubMed=9299262).
Omics: Chromatin accessibility by ATAC-seq.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; c.919+1G>T (IVS8+1G>T); ClinVar=VCV000495326; Zygosity=Homozygous; Note=Splice donor mutation (DepMap).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,33:03
HLA-BB*44:02,54:01
HLA-CC*14:03,14:03
Class II
HLA-DQDQA1*04:01,04:01
DQB1*03:23,03:23
HLA-DRDRB1*04:03,13:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.15
Native American0.59
East Asian, North63.21
East Asian, South35.03
South Asian0
European, North0
European, South0.02
Disease Uterine carcinosarcoma (NCIt: C42700)
Carcinosarcoma of the corpus uteri (ORDO: Orphanet_213610)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): KCLB

Markers:
AmelogeninX
CSF1PO11
D3S135814
D5S81812
D7S8208,12
D13S3178
FGA21
TH016,9.3
TPOX9
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=9299262; DOI=10.1006/gyno.1997.4802
Yuan Y., Kim W.-H., Han H.S., Lee J.-H., Park H.-S., Chung J.-K., Kang S.-B., Park J.-G.
Establishment and characterization of cell lines derived from uterine malignant mixed Mullerian tumor.
Gynecol. Oncol. 66:464-474(1997)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections (Providers) KCLB; 00685
Cell line databases/resources cancercelllines; CVCL_5083
Cell_Model_Passport; SIDM00165
DepMap; ACH-000407
Biological sample resources BioSample; SAMN10988056
CRISP screens repositories BioGRID_ORCS_Cell_line; 697
Chemistry resources PharmacoDB; SNU685_1478_2019
Encyclopedic resources Wikidata; Q54955250
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM888726
GEO; GSM3161726
GEO; GSM3161727
Polymorphism and mutation databases IARC_TP53; 28262
LiGeA; CCLE_719
Progenetix; CVCL_5083
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number27