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Cellosaurus SNU-254 (CVCL_5041)

[Text version]
Cell line name SNU-254
Synonyms SNU254
Accession CVCL_5041
Resource Identification Initiative To cite this cell line use: SNU-254 (RRID:CVCL_5041)
Comments Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 50 hours (PubMed=20176655).
Microsatellite instability: Stable (MSS) (PubMed=20176655; PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Leu1488Tyrfs*19 (c.4463delT); ClinVar=VCV000428136; Zygosity=Unspecified (PubMed=20176655).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=20176655).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu286Lys (c.856G>A); ClinVar=VCV000183752; Zygosity=Unspecified (PubMed=20176655).
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): KCLB=00254; PubMed=20176655; PubMed=25926053

Markers:
AmelogeninX
CSF1PO10,11
D2S133823
D3S135816,17
D5S81810,11
D7S82011,13 (KCLB=00254; PubMed=20176655)
13 (PubMed=25926053)
D8S117913,15
D13S31711
D16S5399
D18S5112
D19S43312,15.2
D21S1131
FGA24,25
TH017
TPOX8,12
vWA14,17

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Publications

PubMed=20176655; DOI=10.1093/carcin/bgq043
Ku J.-L., Shin Y.-K., Kim D.-W., Kim K.-H., Choi J.-S., Hong S.-H., Jeon Y.-K., Kim S.-H., Kim H.-S., Park J.-H., Kim I.-J., Park J.-G.
Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers.
Carcinogenesis 31:1003-1009(2010)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references
Cell line collections (Providers) KCLB; 00254
Cell line databases/resources cancercelllines; CVCL_5041
ColonAtlas; SNU254
Encyclopedic resources Wikidata; Q54955157
Gene expression databases GEO; GSM1448207
Polymorphism and mutation databases Cosmic; 1322283
IARC_TP53; 28469
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number23