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Cellosaurus SNU-251 (CVCL_5040)

[Text version]
Cell line name SNU-251
Synonyms SNU251
Accession CVCL_5040
Resource Identification Initiative To cite this cell line use: SNU-251 (RRID:CVCL_5040)
Comments Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 46 hours (PubMed=9299249).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 1100; BRCA1; Simple; p.Trp1815Ter (c.5445G>A); ClinVar=VCV000055581; Zygosity=Homozygous or hemizygous (PubMed=9299249).
  • Mutation; HGNC; 7127; MLH1; Simple; p.Ala723Asp (c.2168C>A); Zygosity=Heterozygous (PubMed=9299249).
Disease BRCA1-associated hereditary breast and ovarian cancer syndrome (NCIt: C36100)
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): KCLB=00251; PubMed=22710073

Markers:
AmelogeninX
CSF1PO10,12
D2S133819,22
D3S135815,16
D5S81811
D7S82010,12
D8S117911,13
D13S3179
D16S53911
D18S5114,15
D19S43313.2,14.2
D21S1130,31.2
FGA20
TH018
TPOX12
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=9299249; DOI=10.1006/gyno.1997.4785
Yuan Y., Kim W.-H., Han H.S., Lee J.-H., Park H.-S., Chung J.-K., Kang S.-B., Park J.-G.
Establishment and characterization of human ovarian carcinoma cell lines.
Gynecol. Oncol. 66:378-387(1997)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Stordal B., Timms K., Farrelly A., Gallagher D., Busschots S., Renaud M., Thery J., Williams D., Potter J., Tran T., Korpanty G., Cremona M., Carey M.S., Li J., Li Y., Aslan O., O'Leary J.J., Mills G.B., Hennessy B.T.
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

Cross-references
Cell line collections (Providers) KCLB; 00251
Cell line databases/resources cancercelllines; CVCL_5040
Encyclopedic resources Wikidata; Q54955155
Experimental variables resources EFO; EFO_0022583
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number24