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Cellosaurus SNU-1746 (CVCL_5030)

[Text version]
Cell line name SNU-1746
Synonyms SNU1746
Accession CVCL_5030
Resource Identification Initiative To cite this cell line use: SNU-1746 (RRID:CVCL_5030)
Comments Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 42 hours (PubMed=20176655).
Microsatellite instability: Instable (MSI-high) (PubMed=20176655; PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr562fs*19 (c.1682_1683insA); Zygosity=Heterozygous (PubMed=20176655).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1429Ter (c.4285C>T); ClinVar=VCV000376063; Zygosity=Heterozygous (PubMed=20176655).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (PubMed=20176655).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=20176655).
  • Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Glu523Lys (c.1567G>A); Zygosity=Homozygous (PubMed=20176655).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=20176655).
Disease Colon signet ring cell adenocarcinoma (NCIt: C7967)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): KCLB=01746; PubMed=20176655; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO7,9
D2S133818,24
D3S135814,17
D5S81811,12,13 (KCLB=01746)
11,12,13,14 (PubMed=25926053)
12,13 (PubMed=20176655)
D7S8208,11
D8S117911
D13S3179
D16S5399,14
D18S5113,18
D19S43313,17.2
D21S1128,33
FGA17,22
TH016
TPOX8,9
vWA15,18 (KCLB=01746; PubMed=20176655)
18 (PubMed=25926053)

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Publications

PubMed=20176655; DOI=10.1093/carcin/bgq043
Ku J.-L., Shin Y.-K., Kim D.-W., Kim K.-H., Choi J.-S., Hong S.-H., Jeon Y.-K., Kim S.-H., Kim H.-S., Park J.-H., Kim I.-J., Park J.-G.
Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers.
Carcinogenesis 31:1003-1009(2010)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references
Cell line collections (Providers) KCLB; 01746
Cell line databases/resources cancercelllines; CVCL_5030
ColonAtlas; SNU1746
Encyclopedic resources Wikidata; Q54955128
Gene expression databases GEO; GSM1448206
Polymorphism and mutation databases Cosmic; 1322294
IARC_TP53; 28483
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number25