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Cellosaurus A549.EpoB40 (CVCL_4Z15)

[Text version]
Cell line name A549.EpoB40
Synonyms EpoB40
Accession CVCL_4Z15
Resource Identification Initiative To cite this cell line use: A549.EpoB40 (RRID:CVCL_4Z15)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_31550; Epothilone B (EpoB).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=12467233
He L.-F., Yang C.-P.H., Horwitz S.B.
Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.
Mol. Cancer Ther. 1:3-10(2001)

PubMed=15956256; DOI=10.1158/1535-7163.MCT-05-0024
Yang C.-P.H., Verdier-Pinard P., Wang F., Lippaine-Horvath E., He L.-F., Li D.-S., Hofle G., Ojima I., Orr G.A., Horwitz S.B.
A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.
Mol. Cancer Ther. 4:987-995(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Z15
Encyclopedic resources Wikidata; Q54607056
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number11