ID   MCF-7/AdrVp
AC   CVCL_4Y46
SY   MCF7/AdrVp; MCF-7-ADRVP; MCF-7 AdVp; MCF-7/AdrVp(100)
DR   cancercelllines; CVCL_4Y46
DR   Wikidata; Q54904351
RX   PubMed=1972154;
RX   PubMed=7819048;
RX   PubMed=9865745;
RX   PubMed=14576842;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Selected for resistance to: ChEBI; CHEBI:9948; Verapamil (VPL).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 13
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RX   PubMed=1972154; DOI=10.1016/S0021-9258(19)38781-2;
RA   Chen Y.-N., Mickley L.A., Schwartz A.M., Acton E.M., Hwang J.-L.,
RA   Fojo A.T.;
RT   "Characterization of adriamycin-resistant human breast cancer cells
RT   which display overexpression of a novel resistance-related membrane
RT   protein.";
RL   J. Biol. Chem. 265:10073-10080(1990).
//
RX   PubMed=7819048; DOI=10.1038/bjc.1995.11; PMCID=PMC2033479;
RA   Doyle L.A., Ross D.D., Sridhara R., Fojo A.T., Kaufmann S.H.,
RA   Lee E.J., Schiffer C.A.;
RT   "Expression of a 95 kDa membrane protein is associated with low
RT   daunorubicin accumulation in leukaemic blast cells.";
RL   Br. J. Cancer 71:52-58(1995).
//
RX   PubMed=9865745;
RA   Rabindran S.K., He H.-Y., Singh M., Brown E., Collins K.I., Annable T.,
RA   Greenberger L.M.;
RT   "Reversal of a novel multidrug resistance mechanism in human colon
RT   carcinoma cells by fumitremorgin C.";
RL   Cancer Res. 58:5850-5858(1998).
//
RX   PubMed=14576842; DOI=10.1038/sj.onc.1206938;
RA   Doyle L.A., Ross D.D.;
RT   "Multidrug resistance mediated by the breast cancer resistance protein
RT   BCRP (ABCG2).";
RL   Oncogene 22:7340-7358(2003).
//