Cellosaurus logo
expasy logo

Cellosaurus MDA-MB-231 25PACR (CVCL_4Y38)

[Text version]
Cell line name MDA-MB-231 25PACR
Accession CVCL_4Y38
Resource Identification Initiative To cite this cell line use: MDA-MB-231 25PACR (RRID:CVCL_4Y38)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=25312014; DOI=10.1186/1471-2407-14-762; PMCID=PMC4203938
Kenicer J., Spears M., Lyttle N., Taylor K.J., Liao L., Cunningham C.A., Lambros M.B., Mackay A., Yao C., Reis-Filho J.S., Bartlett J.M.S.
Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance.
BMC Cancer 14:762.1-762.10(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Y38
Encyclopedic resources Wikidata; Q54904580
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number18