Cellosaurus logo
expasy logo

Cellosaurus NCI-H3122-CHR-A1 (CVCL_4Y37)

[Text version]
Cell line name NCI-H3122-CHR-A1
Synonyms H3122-CHR-A1; H3122 CHR-A1
Accession CVCL_4Y37
Resource Identification Initiative To cite this cell line use: NCI-H3122-CHR-A1 (RRID:CVCL_4Y37)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_62268; Alectinib (CH5424802; RO5424802; AF-802).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5160 (NCI-H3122)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=25228534; DOI=10.1158/1078-0432.CCR-14-1511; PMCID=PMC4233168
Katayama R., Friboulet L., Koike S., Lockerman E.L., Khan T.M., Gainor J.F., Iafrate A.J., Takeuchi K., Taiji M., Okuno Y., Fujita N., Engelman J.A., Shaw A.T.
Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib.
Clin. Cancer Res. 20:5686-5696(2014)

Cross-references
Encyclopedic resources Wikidata; Q54872052
Polymorphism and mutation databases Cosmic; 2245572
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number9