| Cell line name |
DU-145 R |
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| Accession |
CVCL_4Y36 |
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| Resource Identification Initiative |
To cite this cell line use: DU-145 R (RRID:CVCL_4Y36) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:4672; Docetaxel anhydrous (Taxotere).
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955. |
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| Sequence variations |
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Prostate carcinoma (NCIt: C4863) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0105 (DU145) |
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| Sex of cell |
Male |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=21982118; DOI=10.1186/1476-4598-10-126; PMCID=PMC3203088
O'Neill A.J., Prencipe M., Dowling C., Fan Y., Mulrane L., Gallagher W.M., O'Connor D., O'Connor R., Devery A.M., Corcoran C., Rani S., O'Driscoll L., Fitzpatrick J.M., Watson R.W.G.
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines.
Mol. Cancer 10:126.1-126.13(2011) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_4Y36
|
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| Encyclopedic resources |
Wikidata; Q54831571
|
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| Entry history |
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| Entry creation | 14-Dec-2015 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 14 |
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