ID   Huh7S1
AC   CVCL_4W53
DR   cancercelllines; CVCL_4W53
DR   Wikidata; Q54896862
RX   PubMed=23111106;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:50924; Sorafenib (Nexavar).
CC   Sequence variation: Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0336 ! Huh-7
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 13
//
RX   PubMed=23111106; DOI=10.1016/j.canlet.2012.10.021;
RA   van Malenstein H., Dekervel J., Verslype C., Van Cutsem E.,
RA   Windmolders P., Nevens F., van Pelt J.F.;
RT   "Long-term exposure to sorafenib of liver cancer cells induces
RT   resistance with epithelial-to-mesenchymal transition, increased
RT   invasion and risk of rebound growth.";
RL   Cancer Lett. 329:74-83(2013).
//