| Cell line name |
J82-NVB |
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| Accession |
CVCL_4V98 |
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| Resource Identification Initiative |
To cite this cell line use: J82-NVB (RRID:CVCL_4V98) |
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| Comments |
Population: Caucasian; Swedish.
Doubling time: 19 + 4 hours (PubMed=9137463).
Selected for resistance to: ChEBI; CHEBI_480999; Vinorelbine (Navelbine; NVB).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255. |
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| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Ser770Pro (c.2308T>C); ClinVar=VCV000140988; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro124Leu (c.371C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn212fs*1 (c.635_1212del578); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:9884; RB1; Simple; c.2107-2A>G; ClinVar=VCV000013077; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu271Lys (c.811G>A); ClinVar=VCV000406566; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys320Asn (c.960G>C); Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Bladder carcinoma (NCIt: C4912) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0359 (J82) |
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| Sex of cell |
Male |
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| Age at sampling |
58Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=7981063; DOI=10.1038/bjc.1994.458; PMCID=PMC2033680
Debal V., Allam N., Morjani H., Millot J.-M., Braguer D., Breillout F., Manfait M.
Characterisation of a navelbine-resistant bladder carcinoma cell line cross-resistant to taxoids.
Br. J. Cancer 70:1118-1125(1994) PubMed=9137463
Debal V., Breillout F., Manfait M.
Concomitant decrease of resistance and modifications of the cytoskeleton after all-trans retinoic acid and phorbol ester treatments in a navelbine-resistant bladder carcinoma cell line.
Anticancer Res. 17:1147-1154(1997) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_4V98
|
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| Encyclopedic resources |
Wikidata; Q54898492
|
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| Entry history |
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| Entry creation | 14-Dec-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 14 |
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