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Cellosaurus K562/AS-3 (CVCL_4V84)

[Text version]
Cell line name K562/AS-3
Accession CVCL_4V84
Resource Identification Initiative To cite this cell line use: K562/AS-3 (RRID:CVCL_4V84)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:30621; Diarsenic trioxide (ATO; As2O3).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=17261498; DOI=10.1532/IJH97.05142
Seo T., Urasaki Y., Ueda T.
Establishment of an arsenic trioxide-resistant human leukemia cell line that shows multidrug resistance.
Int. J. Hematol. 85:26-31(2007)

Cross-references
Encyclopedic resources Wikidata; Q54899405
Entry history
Entry creation14-Dec-2015
Last entry update02-May-2024
Version number15