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Cellosaurus K562-PON[r] (CVCL_4V64)

[Text version]
Cell line name K562-PON[r]
Accession CVCL_4V64
Resource Identification Initiative To cite this cell line use: K562-PON[r] (RRID:CVCL_4V64)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:78543; Ponatinib (AP24534; Iclusig).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Web pages http://www.chemoscreen.com/product/k562-ponr-cells
Cross-references
Encyclopedic resources Wikidata; Q54899398
Entry history
Entry creation14-Dec-2015
Last entry update02-May-2024
Version number15