ID   SKW3/Clo
AC   CVCL_4V58
DR   cancercelllines; CVCL_4V58
DR   Wikidata; Q54954817
RX   PubMed=25461250;
CC   Problematic cell line: Contaminated. Parent cell line (SKW-3) has been shown to be a KE-37 derivative.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:681569; Clofarabine (CAFdA).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Gln2459Ter (c.7375C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9585; PTCH1; Simple; p.Arg571Gln (c.1712G>A); ClinVar=VCV000819886; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Gly310Glu (c.929G>A); ClinVar=VCV000237678; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (from parent cell line).
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2197 ! SKW-3
SX   Male
AG   27Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 12
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RX   PubMed=25461250; DOI=10.1016/j.exphem.2014.11.001;
RA   Yamanishi M., Narazaki H., Asano T.;
RT   "Melatonin overcomes resistance to clofarabine in two leukemic cell
RT   lines by increased expression of deoxycytidine kinase.";
RL   Exp. Hematol. 43:207-214(2015).
//