| Cell line name |
LoVo/irinotecan |
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| Accession |
CVCL_4V50 |
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| Resource Identification Initiative |
To cite this cell line use: LoVo/irinotecan (RRID:CVCL_4V50) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_80630; Irinotecan (Camptothecin-11; CPT-11).
Omics: Proteome analysis by 2D-DE/MS.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1114Ter (c.3340C>T); ClinVar=VCV000236589; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Met1431fs*42 (c.4289delC) (p.T1430fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Arg2816Gln (c.8447G>A); ClinVar=VCV000419681; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6768; SMAD2; Simple; p.Ala292Val (c.875C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0399 (LoVo) |
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| Sex of cell |
Male |
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| Age at sampling |
56Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=21289438; DOI=10.1007/s12038-010-0064-9
Peng X.-C., Gong F.-M., Wei M., Chen X., Chen Y., Cheng K., Gao F., Xu F., Bi F., Liu J.-Y.
Proteomic analysis of cell lines to identify the irinotecan resistance proteins.
J. Biosci. 35:557-564(2010) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_4V50
|
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| Encyclopedic resources |
Wikidata; Q54902905
|
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| Entry history |
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| Entry creation | 14-Dec-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 16 |
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