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Cellosaurus A2780/TPT (CVCL_4V45)

[Text version]
Cell line name A2780/TPT
Accession CVCL_4V45
Resource Identification Initiative To cite this cell line use: A2780/TPT (RRID:CVCL_4V45)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_63632; Topotecan.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=14693055
Jia P., Wu S.-B., Xu Q., Wu M.-F., Gao Q.-L., Liao G.-N., Lu Y.-P., Ma D.
Antisense oligonucleotide reverses topotecan-resistant ovarian cancer cells.
Ai Zheng 22:1296-1300(2003)

DOI=10.3969/j.issn.1004-7379.2004.03.003
Jia P., Li F., Wu M.-F., Liao G.-N., Lu Y.-P., Ma D.
Establishment of topotecan-resistant ovarian cancer cell line.
Xian Dai Fu Chan Ke Jin Zhan 13:174-177(2004)

PubMed=15196431; DOI=10.3760/j.issn:0253-3766.2004.03.003
Jia P., Wu S.-B., Li F., Xu Q., Wu M.-F., Liao G.-N., Lu Y.-P., Ma D.
The mechanism of topotecan resistance in ovarian cancer cell line.
Zhonghua Zhong Liu Za Zhi 26:139-142(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V45
Encyclopedic resources Wikidata; Q54606611
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number11