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Cellosaurus HBMEC/cibeta (CVCL_4U95)

[Text version]
Cell line name HBMEC/cibeta
Synonyms HBMEC/cib; Human BMEC/conditionally immortalized, clone beta
Accession CVCL_4U95
Resource Identification Initiative To cite this cell line use: HBMEC/cibeta (RRID:CVCL_4U95)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Proteomics; Subcellular; Membrane; Quantitative.
Derived from site: In situ; Brain, endothelium; UBERON=UBERON_0013694.
Cell type: Brain microvascular endothelial cell; CL=CL_2000044.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Category Conditionally immortalized cell line
Publications

PubMed=23041702; DOI=10.1016/j.brainres.2012.09.042
Kamiichi A., Furihata T., Kishida S., Ohta Y., Saito K., Kawamatsu S., Chiba K.
Establishment of a new conditionally immortalized cell line from human brain microvascular endothelial cells: a promising tool for human blood-brain barrier studies.
Brain Res. 1488:113-122(2012)

PubMed=25763180; DOI=10.1186/s12987-015-0003-0; PMCID=PMC4355132
Furihata T., Kawamatsu S., Ito R., Saito K., Suzuki S., Kishida S., Saito Y., Kamiichi A., Chiba K.
Hydrocortisone enhances the barrier properties of HBMEC/cibeta, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects.
Fluids Barriers CNS 12:7.1-7.15(2015)

PubMed=30983357; DOI=10.1021/acs.molpharmaceut.9b00114
Masuda T., Hoshiyama T., Uemura T., Hirayama-Kurogi M., Ogata S., Furukawa A., Couraud P.-O., Furihata T., Ito S., Ohtsuki S.
Large-scale quantitative comparison of plasma transmembrane proteins between two human blood-brain barrier model cell lines, hCMEC/D3 and HBMEC/cibeta.
Mol. Pharm. 16:2162-2171(2019)

Cross-references
Encyclopedic resources Wikidata; Q54881448
Entry history
Entry creation14-Dec-2015
Last entry update10-Apr-2025
Version number13