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Cellosaurus A2780-DX1 (CVCL_4T95)

[Text version]
Cell line name A2780-DX1
Accession CVCL_4T95
Resource Identification Initiative To cite this cell line use: A2780-DX1 (RRID:CVCL_4T95)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Children:
CVCL_4T96 (A2780-DX2)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2598402; DOI=10.1007/BF00692343
Alaoui-Jamali M.A., Yin M.-B., Mazzoni A., Bankusli I., Rustum Y.M.
Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933.
Cancer Chemother. Pharmacol. 25:77-83(1989)

PubMed=2243668; DOI=10.1159/000226878
Mazzoni A., Trave F., Russo P., Nicolin A., Rustum Y.M.
Generation and characterization of a low-degree drug-resistant human tumor cell line.
Oncology 47:488-494(1990)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4T95
Encyclopedic resources Wikidata; Q54606565
Entry history
Entry creation22-Sep-2015
Last entry update19-Dec-2024
Version number12