ID   MES-SA/DxP5002
AC   CVCL_4T94
SY   DxP
DR   cancercelllines; CVCL_4T94
DR   Wikidata; Q54905251
RX   PubMed=9038218;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11110; ARID1A; Simple; p.Gly1610Trpfs*38 (c.4826dupC) (p.S1609fs) (c.4825_4826insC); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11110; ARID1A; Simple; p.Thr1690Asnfs*8 (c.5068dupA) (c.5067_5068insA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.His272Thrfs*4 (c.813delT) (p.Phe271fs) (c.811delT); ClinVar=VCV000428208; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Uterus; UBERON=UBERON_0000995.
DI   NCIt; C6339; Uterine corpus sarcoma
DI   ORDO; Orphanet_213620; Sarcoma of the corpus uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2598 ! MES-SA/Dx5
SX   Female
AG   56Y
CA   Cancer cell line
DT   Created: 22-09-15; Last updated: 05-10-23; Version: 9
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RX   PubMed=9038218; DOI=10.1074/jbc.272.9.5974;
RA   Chen G., Duran G.E., Steger K.A., Lacayo N.J., Jaffrezou J.-P.,
RA   Dumontet C., Sikic B.I.;
RT   "Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein,
RT   altered phenotype, and resistance to cyclosporins.";
RL   J. Biol. Chem. 272:5974-5982(1997).
//