Cellosaurus cell line MP65 (CVCL

Cellosaurus MP65 (CVCL_4D14)

[Text version]

Cell line name

MP65

Accession

CVCL_4D14

Resource Identification Initiative

To cite this cell line use: MP65 (RRID:CVCL_4D14)

Comments

Doubling time: 120 hours (PubMed=24994677).
Omics: SNP array analysis.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.

Sequence variations

Mutation; HGNC; HGNC:950; BAP1; Simple; p.Leu573Trpfs*3 (c.1717delC); ClinVar=VCV000221278; Zygosity=Unspecified (PubMed=24994677).
Mutation; HGNC; HGNC:4379; GNA11; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000376002; Zygosity=Unspecified (PubMed=24994677).

Disease

Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

42Y

Category

Cancer cell line

STR profile

Source(s): ATCC=CRL-3299; PubMed=24994677

Markers:

Amelogenin	X
CSF1PO	10
D5S818	12
D7S820	8,11
D13S317	8 (ATCC=CRL-3299) 8,13 (PubMed=24994677)
D16S539	11
D21S11	30,30.2
TH01	7,9.3
TPOX	8,12
vWA	14,18

Publications

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Amirouchene-Angelozzi N., Nemati F., Gentien D., Nicolas A., Dumont A., Carita G., Camonis J., Desjardins L., Cassoux N., Piperno-Neumann S., Mariani P., Sastre-Garau X., Decaudin D., Roman-Roman S.
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

Cross-references

Cell line collections (Providers)

ATCC; CRL-3299

Cell line databases/resources

cancercelllines; CVCL_4D14

Encyclopedic resources

Wikidata; Q54906431

Entry history

Entry creation

22-Sep-2015

Last entry update

19-Dec-2024

Version number