Cellosaurus logo
expasy logo

Cellosaurus MCF-7/CG-5 (CVCL_4D04)

[Text version]
Cell line name MCF-7/CG-5
Synonyms CG-5; CG5
Accession CVCL_4D04
Resource Identification Initiative To cite this cell line use: MCF-7/CG-5 (RRID:CVCL_4D04)
Comments Population: Caucasian.
Characteristics: Estrogen supersensitive (PubMed=6575841).
Doubling time: 13 hours (PubMed=8712686).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Children:
CVCL_4D05 (MCF-7/CG-5/Dx)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=6575841; DOI=10.1007/BF01806231
Natoli C., Sica G., Natoli V., Serra A., Iacobelli S.
Two new estrogen-supersensitive variants of the MCF-7 human breast cancer cell line.
Breast Cancer Res. Treat. 3:23-32(1983)

PubMed=3516389
Iacobelli S., Arno E., D'Orazio A., Coletti G.
Detection of antigens recognized by a novel monoclonal antibody in tissue and serum from patients with breast cancer.
Cancer Res. 46:3005-3010(1986)

PubMed=8712686
Gibelli N., Zibera C., Asti A., Maestri L., Bacchella L., Pedrazzoli P., Calligaro A., Robustelli della Cuna G.
CG5/Dx human breast cancer cell line: characterization of a new doxorubicin-resistant variant.
Anticancer Res. 16:1675-1681(1996)

Cross-references
Cell line databases/resources CLO; CLO_0002398
cancercelllines; CVCL_4D04
Encyclopedic resources Wikidata; Q54904360
Entry history
Entry creation22-Sep-2015
Last entry update19-Dec-2024
Version number16