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Cellosaurus HL-60/Vinc (CVCL_4967)

[Text version]
Cell line name HL-60/Vinc
Synonyms HL60/Vinc
Accession CVCL_4967
Resource Identification Initiative To cite this cell line use: HL-60/Vinc (RRID:CVCL_4967)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=2886122; DOI=10.1016/0006-291X(87)91560-9
McGrath T., Center M.S.
Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein.
Biochem. Biophys. Res. Commun. 145:1171-1176(1987)

PubMed=2573357; DOI=10.1016/0006-2952(89)90134-2
McGrath T., Latoud C., Arnold S.T., Safa A.R., Felsted R.L., Center M.S.
Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression.
Biochem. Pharmacol. 38:3611-3619(1989)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4967
Anatomy/cell type resources BTO; BTO_0002591
Encyclopedic resources Wikidata; Q54889810
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number23