ID   SSP-25
AC   CVCL_4902
SY   SSP25
DR   CLO; CLO_0050849
DR   BioSample; SAMN03472126
DR   Cell_Model_Passport; SIDM00275
DR   Cosmic; 1187339
DR   Cosmic; 1571786
DR   Cosmic; 2629287
DR   DepMap; ACH-001858
DR   RCB; RCB1293
DR   Wikidata; Q54955717
RX   CelloPub=CLPUB00275;
RX   PubMed=9358283;
RX   PubMed=15767549;
RX   PubMed=27231123;
RX   PubMed=31077409;
RX   PubMed=35640676;
WW   https://cell.brc.riken.jp/en/rcb/rbessp-25_announce
CC   Problematic cell line: Contaminated. Shown to be a ETK-1 derivative (RCB=RCB1293). Originally thought to originate from a 64 year old female patient with an intrahepatic cholangiocarcinoma.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: JFCR45 cancer cell line panel.
CC   Population: Japanese.
CC   Doubling time: 64 hours (PubMed=9358283).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): DepMap; RCB
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12
ST   D16S539: 10,12
ST   D18S51: 21
ST   D21S11: 29
ST   D3S1358: 15
ST   D5S818: 10
ST   D7S820: 11
ST   D8S1179: 10,12
ST   FGA: 19,25
ST   Penta D: 14
ST   Penta E: 15
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 14,17
DI   NCIt; C35417; Intrahepatic cholangiocarcinoma
DI   ORDO; Orphanet_70567; Cholangiocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1206 ! ETK-1
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 27
//
RX   CelloPub=CLPUB00275;
RA   Zach S., Birgin E., Ruckert F.;
RT   "Primary cholangiocellular carcinoma cell lines.";
RL   J. Stem Cell Res. Transplant. 2:1013-1013(2015).
//
RX   PubMed=9358283; DOI=10.1007/s11626-997-0125-z;
RA   Enjoji M., Sakai H., Nawata H., Kajiyama K., Tsuneyoshi M.;
RT   "Sarcomatous and adenocarcinoma cell lines from the same nodule of
RT   cholangiocarcinoma.";
RL   In Vitro Cell. Dev. Biol. Anim. 33:681-683(1997).
//
RX   PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234;
RA   Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y.,
RA   Yamori T.;
RT   "Chemosensitivity profile of cancer cell lines and identification of
RT   genes determining chemosensitivity by an integrated bioinformatical
RT   approach using cDNA arrays.";
RL   Mol. Cancer Ther. 4:399-412(2005).
//
RX   PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442;
RA   Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C.,
RA   Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K.,
RA   Greninger P., McDermott U., Garnett M.J., Jenkins R.L.,
RA   Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y.,
RA   Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H.,
RA   El-Bardeesy N.;
RT   "Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity
RT   and SRC dependence in intrahepatic cholangiocarcinoma.";
RL   Cancer Discov. 6:727-739(2016).
//
RX   PubMed=31077409; DOI=10.1002/hep.30704;
RA   Sittithumcharee G., Suppramote O., Vaeteewoottacharn K.,
RA   Sirisuksakun C., Jamnongsong S., Laphanuwat P., Suntiparpluacha M.,
RA   Matha A., Chusorn P., Buraphat P., Kakanaporn C., Charngkaew K.,
RA   Silsirivanit A., Korphaisarn K., Limsrichamrern S., Tripatara P.,
RA   Pairojkul C., Wongkham S., Sampattavanich S., Okada S.,
RA   Jirawatnotai S.;
RT   "Dependency of cholangiocarcinoma on cyclin D-dependent kinase
RT   activity.";
RL   Hepatology 70:1614-1630(2019).
//
RX   PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007;
RA   Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y.,
RA   Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S.,
RA   Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.;
RT   "Development and characterization of human primary cholangiocarcinoma
RT   cell lines.";
RL   Am. J. Pathol. 192:1200-1217(2022).
//