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Cellosaurus SR DU-145 (CVCL_4901)

[Text version]
Cell line name SR DU-145
Synonyms SR DU 145; SR DU145
Accession CVCL_4901
Resource Identification Initiative To cite this cell line use: SR DU-145 (RRID:CVCL_4901)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45906; Suramin.
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0105 (DU145)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=9923549; DOI=10.1007/s002800050884
Church D., Zhang Y.-L., Rago R.P., Wilding G.
Efficacy of suramin against human prostate carcinoma DU145 xenografts in nude mice.
Cancer Chemother. Pharmacol. 43:198-204(1999)

PubMed=15643172; DOI=10.1097/01.ju.0000141580.30910.57
Sobel R.E., Sadar M.D.
Cell lines used in prostate cancer research: a compendium of old and new lines -- part 1.
J. Urol. 173:342-359(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4901
Encyclopedic resources Wikidata; Q54955623
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number21