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Cellosaurus MX-1 (CVCL_4774)

[Text version]
Cell line name MX-1
Synonyms MX1; MXI
Accession CVCL_4774
Resource Identification Initiative To cite this cell line use: MX-1 (RRID:CVCL_4774)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: GrayJW breast cancer cell line panel.
Population: Caucasian.
Characteristics: Established from a tumor xenograft established in atyhmic mice.
Doubling time: 30-35 hours (CLS=300296); 113.83 hours (GrayJW panel).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln52Valfs*3 (c.154_158delCAATG); Zygosity=Unspecified (PubMed=29045385).
HLA typing Source: PubMed=25960936
Class I
Class II

Source: PubMed=26589293
Class I
Class II
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 29Y
Category Cancer cell line
STR profile Source(s): CLS; PubMed=25877200

D7S82011 (PubMed=25877200)
11,12 (CLS)
D8S117911 (PubMed=25877200)
11,12,13 (CLS)
D13S31711 (PubMed=25877200)
11,12 (CLS)
D21S1129,30,31,32 (CLS)
29,32 (PubMed=25877200)
Penta D6,9,11
Penta E14
8 (PubMed=25877200)
vWA17 (PubMed=25877200)
17,18 (CLS)

Run an STR similarity search on this cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255

Forozan F., Mahlamaki E.H., Monni O., Chen Y.-D., Veldman R., Jiang Y., Gooden G.C., Ethier S.P., Kallioniemi A., Kallioniemi O.-P.
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.
Cancer Res. 60:4519-4525(2000)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29045385; DOI=10.1038/nature24006
Kategaya L., Di Lello P., Rouge L., Pastor R., Clark K.R., Drummond J., Kleinheinz T., Lin E., Upton J.-P., Prakash S., Heideker J., McCleland M.L., Ritorto M.S., Alessi D.R., Trost M., Bainbridge T.W., Kwok M.C.M., Ma T.P., Stiffler Z., Brasher B., Tang Y.-Y., Jaishankar P., Hearn B.R., Renslo A.R., Arkin M.R., Cohen F., Yu K.-B., Peale F.V., Gnad F., Chang M.T., Klijn C., Blackwood E., Martin S.E., Forrest W.F., Ernst J.A., Ndubaku C., Wang X.-J., Beresini M.H., Tsui V., Schwerdtfeger C., Blake R.A., Murray J., Maurer T., Wertz I.E.
USP7 small-molecule inhibitors interfere with ubiquitin binding.
Nature 550:534-538(2017)

Cell line collections (Providers) CLS; 300296
Cell line databases/resources CLO; CLO_0009915
DepMap; ACH-002328
LINCS_HMS; 51090
Anatomy/cell type resources BTO; BTO:0004179
Biological sample resources BioSample; SAMN03472921
Chemistry resources ChEMBL-Cells; CHEMBL3308046
ChEMBL-Targets; CHEMBL613704
PharmacoDB; MX1_973_2019
PubChem_Cell_line; CVCL_4774
Encyclopedic resources Wikidata; Q54907134
Experimental variables resources EFO; EFO_0006457
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM845398
GEO; GSM844612
GEO; GSM844611
GEO; GSM844613
GEO; GSM1172987
GEO; GSM1172893
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26