ID   TC-1 [Mouse lung]
AC   CVCL_4699
SY   TC-1[JHU-1]; Tissue Culture-1
DR   BTO; BTO_0004795
DR   CLO; CLO_0009279
DR   ATCC; CRL-2785
DR   ATCC; JHU-1
DR   NCBI_Iran; C569
DR   Wikidata; Q54971787
RX   PubMed=8548765;
RX   PubMed=12559790;
RX   PubMed=31638243;
CC   Doubling time: 18.2 hours (PubMed=12559790); 18.5 hours (PubMed=31638243).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Discontinued: ATCC; CRL-2785; true.
CC   Discontinued: ATCC; JHU-1; true.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Epithelial cell; CL=CL_0000066.
CC   Breed/subspecies: C57BL/6.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 24
CH   CVCL_ZW99 ! TC-1/A9
CH   CVCL_ZX00 ! TC-1/D11
CH   CVCL_ZX01 ! TC-1/dB2m
CH   CVCL_B6PJ ! TC-1/E2
//
RX   PubMed=31638243; DOI=10.3892/or.2019.7356;
RA   Lhotakova, Karolina
RA   Grzelak, Adrianna
RA   Polakova, Ingrid
RA   Vackova, Julie
RA   Smahel, Michal
RT   "Establishment and characterization of a mouse tumor cell line with
RT   irreversible downregulation of MHC class I molecules.";
RL   Oncol. Rep. 42:2826-2835(2019).
//
RX   PubMed=8548765;
RA   Lin, Ken-Yu
RA   Guarnieri, Frank G.
RA   Staveley-O'Carroll, Kevin Finnbar
RA   Levitsky, Hyam I.
RA   August, J. Thomas
RA   Pardoll, Drew Mark
RA   Wu, Tzyy-Choou
RT   "Treatment of established tumors with a novel vaccine that enhances
RT   major histocompatibility class II presentation of tumor antigen.";
RL   Cancer Res. 56:21-26(1996).
//
RX   PubMed=12559790; DOI=10.1016/S0264-410x(02)00519-4;
RA   Smahel, Michal
RA   Sima, Pavel
RA   Ludvikova, Viera
RA   Marinov, Iuri
RA   Pokorna, Dana
RA   Vonka, Vladimir
RT   "Immunisation with modified HPV16 E7 genes against mouse oncogenic
RT   TC-1 cell sublines with downregulated expression of MHC class I
RT   molecules.";
RL   Vaccine 21:1125-1136(2003).
//