ID   DT40-ITRP1(-/-)-ITPR2(-/-)-ITPR3(-/-)
AC   CVCL_4634
AS   CVCL_8B34
SY   IP3R^(-) DT40; DT40-3KO; DT40 3KO; DT-40 3KO; Dt-40 3ko
DR   BTO; BTO:0005034
DR   CLO; CLO_0051504
DR   RCB; RCB1467
DR   Wikidata; Q54831488
RX   PubMed=9214625;
RX   PubMed=27048566;
CC   Group: Bird cell line.
CC   Knockout cell: Method=Targeted integration; UniProtKB; A0A8V0ZEC6; ITPR1.
CC   Knockout cell: Method=Targeted integration; UniProtKB; F1P1X4; ITPR2.
CC   Knockout cell: Method=Targeted integration; UniProtKB; A0A8V1ACE6; ITPR3.
CC   Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
CC   Cell type: B-cell; CL=CL_0000236.
CC   Breed/subspecies: Hy-Line SC.
DI   NCIt; C134556; Chicken bursal lymphoma
OX   NCBI_TaxID=9031; ! Gallus gallus (Chicken)
HI   CVCL_0249 ! DT40
SX   Female
AG   1D
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 15
//
RX   PubMed=9214625; DOI=10.1093/emboj/16.11.3078;
RA   Sugawara H., Kurosaki M., Takata M., Kurosaki T.;
RT   "Genetic evidence for involvement of type 1, type 2 and type 3
RT   inositol 1,4,5-trisphosphate receptors in signal transduction through
RT   the B-cell antigen receptor.";
RL   EMBO J. 16:3078-3088(1997).
//
RX   PubMed=27048566; DOI=10.1126/scisignal.aad6281;
RA   Alzayady K.J., Wang L.-W., Chandrasekhar R., Wagner L.E. II,
RA   Van Petegem F., Yule D.I.;
RT   "Defining the stoichiometry of inositol 1,4,5-trisphosphate binding
RT   required to initiate Ca2+ release.";
RL   Sci. Signal. 9:Ra35.1-Ra35.13(2016).
//