ID   OE50
AC   CVCL_4628
SY   OE-50; JROECL 50; JROECL50
DR   CLO; CLO_0008242
DR   CLDB; cl3764
DR   cancercelllines; CVCL_4628
DR   Cosmic; 997863
DR   ECACC; 96061337
DR   Wikidata; Q54931867
RX   PubMed=9010035;
RX   PubMed=10789716;
RX   PubMed=23795680;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HCT 116 derivative (PubMed=10789716). Originally thought to originate from a 71 year old female patient with an esophageal squamous cell carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00547.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Discontinued: ECACC; 96061337; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 22
//
RX   PubMed=9010035; DOI=10.1038/bjc.1997.42;
RA   Rockett J.C., Larkin K., Darnton S.J., Morris A.G., Matthews H.R.;
RT   "Five newly established oesophageal carcinoma cell lines: phenotypic
RT   and immunological characterization.";
RL   Br. J. Cancer 75:258-263(1997).
//
RX   PubMed=10789716; DOI=10.1054/bjoc.1999.1170;
RA   Wijnhoven B.P.L., Tilanus M.G.J., Morris A.G., Darnton S.J.,
RA   Tilanus H.W., Dinjens W.N.M.;
RT   "Human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50
RT   are admixtures of the human colon carcinoma cell line HCT 116.";
RL   Br. J. Cancer 82:1510-1512(2000).
//
RX   PubMed=23795680; DOI=10.1111/dote.12095;
RA   Boonstra J.J., Tilanus H.W., Dinjens W.N.M.;
RT   "Translational research on esophageal adenocarcinoma: from cell line
RT   to clinic.";
RL   Dis. Esophagus 28:90-96(2015).
//