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Cellosaurus RF/6A (CVCL_4552)

[Text version]
Cell line name RF/6A
Accession CVCL_4552
Resource Identification Initiative To cite this cell line use: RF/6A (RRID:CVCL_4552)
Comments Group: Non-human primate cell line.
Problematic cell line: Probably misidentified. While originally thought to be an endothelial cell line, it has been shown to lack functional and transcriptomic characteristics of such cell type (PubMed=30508043).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Fetal eye, choroid; UBERON=UBERON_0010312+UBERON_0001776.
Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
Species of origin Macaca mulatta (Rhesus macaque) (NCBI Taxonomy: 9544)
Hierarchy Children:
CVCL_J443 (RF/6A 135)
Sex of cell Sex unspecified
Age at sampling 64FD
Category Spontaneously immortalized cell line

PubMed=3771439; DOI=10.1007/BF02623517
Hu F.-N., Mah K., Teramura D.J.
Gossypol effects on cultured normal and malignant melanocytes.
In Vitro Cell. Dev. Biol. 22:583-588(1986)

PubMed=3102454; DOI=10.1007/BF02623586
Lou D.-A., Hu F.-N.
Specific antigen and organelle expression of a long-term rhesus endothelial cell line.
In Vitro Cell. Dev. Biol. 23:75-85(1987)

PubMed=27259688; DOI=10.3109/02713683.2016.1145234
Li R., Du J.-H., Chang Y.
Role of autophagy in hypoxia-induced angiogenesis of RF/6A cells in vitro.
Curr. Eye Res. 41:1566-1570(2016)

PubMed=30508043; DOI=10.1167/iovs.18-25215
Makin R.D., Apicella I., Nagasaka Y., Kaneko H., Turner S.D., Kerur N., Ambati J., Gelfand B.D.
RF/6A chorioretinal cells do not display key endothelial phenotypes.
Invest. Ophthalmol. Vis. Sci. 59:5795-5802(2018)

Cell line collections (Providers) ATCC; CRL-1780
BCRC; 60558
CLS; 305150
Cell line databases/resources CLO; CLO_0008790
Lonza; 1179
Chemistry resources ChEMBL-Cells; CHEMBL4513118
ChEMBL-Targets; CHEMBL4513132
PubChem_Cell_line; CVCL_4552
Encyclopedic resources Wikidata; Q54949809
Gene expression databases GEO; GSE113674
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number19