ID   TE-2
AC   CVCL_4455
SY   TE2
DR   BTO; BTO:0002866
DR   BioSample; SAMN03151965
DR   cancercelllines; CVCL_4455
DR   Cell_Model_Passport; SIDM00022
DR   CGH-DB; 306-1
DR   CGH-DB; 9255-4
DR   ChEMBL-Cells; CHEMBL3307467
DR   ChEMBL-Targets; CHEMBL615011
DR   Cosmic; 730307
DR   Cosmic; 735782
DR   Cosmic; 801323
DR   Cosmic; 923174
DR   Cosmic; 926098
DR   Cosmic; 947595
DR   Cosmic; 983714
DR   Cosmic; 1123319
DR   Cosmic; 1612897
DR   Cosmic; 2650637
DR   Cosmic; 2698419
DR   GEO; GSM301572
DR   Progenetix; CVCL_4455
DR   PubChem_Cell_line; CVCL_4455
DR   RCB; RCB1948
DR   TKG; TKG 0253
DR   Wikidata; Q54972015
RX   PubMed=520749;
RX   PubMed=1778766;
RX   PubMed=2302677;
RX   PubMed=2420787;
RX   PubMed=2990217;
RX   PubMed=3518877;
RX   PubMed=8509434;
RX   PubMed=9290701;
RX   PubMed=15172977;
RX   PubMed=17804709;
RX   PubMed=18973137;
RX   PubMed=20143388;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. TE-2, TE-3, TE-7, TE-12 and TE-13 have been shown to be identical (PubMed=17804709; PubMed=20143388). TE-2 was originally thought to originate from the primary tumor of the intrathoracic esophagus of a 57 year old Japanese male.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00275.
CC   Population: Japanese.
CC   Doubling time: 72 hours (PubMed=520749).
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by microarray.
CC   Discontinued: RCB; RCB1948; true.
CC   Discontinued: TKG; TKG 0253; true.
DI   NCIt; C4024; Esophageal squamous cell carcinoma
DI   ORDO; Orphanet_99977; Squamous cell carcinoma of the esophagus
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_9971 ! TE-3
OI   CVCL_9972 ! TE-7
OI   CVCL_1762 ! TE-12
OI   CVCL_4463 ! TE-13
SX   Male
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 27
//
RX   PubMed=520749; DOI=10.20772/cancersci1959.70.5_575;
RA   Nishihira T., Kasai M., Mori S., Watanabe T., Kuriya Y., Suda M.,
RA   Kitamura M., Hirayama K., Akaishi T., Sasaki T.;
RT   "Characteristics of two cell lines (TE-1 and TE-2) derived from human
RT   squamous cell carcinoma of the esophagus.";
RL   Gann 70:575-584(1979).
//
RX   PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x;
RA   Takeshima E., Hamaguchi M., Watanabe T., Akiyama S., Kataoka M.,
RA   Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.;
RT   "Aberrant elevation of tyrosine-specific phosphorylation in human
RT   gastric cancer cells.";
RL   Jpn. J. Cancer Res. 82:1428-1435(1991).
//
RX   PubMed=2302677; DOI=10.1016/0165-4608(90)90073-j;
RA   Whang-Peng J., Banks-Schlegel S.P., Lee E.C.;
RT   "Cytogenetic studies of esophageal carcinoma cell lines.";
RL   Cancer Genet. Cytogenet. 45:101-120(1990).
//
RX   PubMed=2420787; DOI=10.1016/S0021-9258(17)38506-X;
RA   Banks-Schlegel S.P., Quintero J.;
RT   "Human esophageal carcinoma cells have fewer, but higher affinity
RT   epidermal growth factor receptors.";
RL   J. Biol. Chem. 261:4359-4362(1986).
//
RX   PubMed=2990217;
RA   Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.;
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=8509434; DOI=10.1007/BF01215923;
RA   Nishihira T., Hashimoto Y., Katayama M., Mori S., Kuroki T.;
RT   "Molecular and cellular features of esophageal cancer cells.";
RL   J. Cancer Res. Clin. Oncol. 119:441-449(1993).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=15172977; DOI=10.1158/0008-5472.CAN-04-0172;
RA   Sonoda I., Imoto I., Inoue J., Shibata T., Shimada Y., Chin K.,
RA   Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.;
RT   "Frequent silencing of low density lipoprotein receptor-related
RT   protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in
RT   esophageal squamous cell carcinoma.";
RL   Cancer Res. 64:3741-3747(2004).
//
RX   PubMed=17804709; DOI=10.1158/0008-5472.CAN-07-2064;
RA   Boonstra J.J., van der Velden A.W., Beerens E.C.W., van Marion R.,
RA   Morita-Fujimura Y., Matsui Y., Nishihira T., Tselepis C., Hainaut P.,
RA   Lowe A.W., Beverloo H.B., van Dekken H., Tilanus H.W., Dinjens W.N.M.;
RT   "Mistaken identity of widely used esophageal adenocarcinoma cell line
RT   TE-7.";
RL   Cancer Res. 67:7996-8001(2007).
//
RX   PubMed=18973137; DOI=10.1002/gcc.20626;
RA   Sugimoto T., Seki N., Shimizu S., Kikkawa N., Tsukada J., Shimada H.,
RA   Sasaki K., Hanazawa T., Okamoto Y., Hata A.;
RT   "The galanin signaling cascade is a candidate pathway regulating
RT   oncogenesis in human squamous cell carcinoma.";
RL   Genes Chromosomes Cancer 48:132-142(2009).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//