ID   IIICF-T/B3
AC   CVCL_4413
SY   LTAG-transformed IIICF clone B3
DR   Wikidata; Q54897432
RX   PubMed=8108114;
RX   PubMed=19468068;
RX   PubMed=22829774;
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Hemizygous; Note=Impairs TP53 splicing dramatically (from parent cell line).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRSV-T).
CC   Caution: Was briefly displayed in Cell Bank Australia under catalog number CBA-0056 but was never intended to be distributed.
CC   Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.
DI   NCIt; C3476; Li-Fraumeni syndrome
DI   ORDO; Orphanet_524; Li-Fraumeni syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4415 ! IIICF/c
SX   Female
AG   30-40Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 17
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RX   PubMed=8108114;
RA   MacLean K., Rogan E.M., Whitaker N.J., Chang A.C.-M., Rowe P.B.,
RA   Dalla-Pozza L., Symonds G., Reddel R.R.;
RT   "In vitro transformation of Li-Fraumeni syndrome fibroblasts by SV40
RT   large T antigen mutants.";
RL   Oncogene 9:719-725(1994).
//
RX   PubMed=19468068; DOI=10.1083/jcb.200810084; PMCID=PMC2711592;
RA   Jiang W.-Q., Zhong Z.-H., Nguyen A., Henson J.D., Toouli C.D.,
RA   Braithwaite A.W., Reddel R.R.;
RT   "Induction of alternative lengthening of telomeres-associated PML
RT   bodies by p53/p21 requires HP1 proteins.";
RL   J. Cell Biol. 185:797-810(2009).
//
RX   PubMed=22829774; DOI=10.1371/journal.pgen.1002772; PMCID=PMC3400581;
RA   Lovejoy C.A., Li W.-D., Reisenweber S., Thongthip S., Bruno J.,
RA   de Lange T., De S., Petrini J.H.J., Sung P.A., Jasin M., Rosenbluh J.,
RA   Zwang Y., Weir B.A., Hatton C., Ivanova E.V., MacConaill L.E., Hanna M.,
RA   Hahn W.C., Lue N.F., Reddel R.R., Jiao Y.-C., Kinzler K.W.,
RA   Vogelstein B., Papadopoulos N., Meeker A.K.;
RG   ALT Starr Cancer Consortium;
RT   "Loss of ATRX, genome instability, and an altered DNA damage response
RT   are hallmarks of the alternative lengthening of telomeres pathway.";
RL   PLoS Genet. 8:E1002772-E1002772(2012).
//