ID   IIICF-T/A6
AC   CVCL_4412
SY   LTAG-transformed IIICF clone A6
DR   Wikidata; Q54897430
RX   PubMed=8108114;
RX   PubMed=9175740;
RX   PubMed=22829774;
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Hemizygous; Note=Impairs TP53 splicing dramatically (from parent cell line).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRSV-T).
CC   Caution: Was briefly displayed in Cell Bank Australia under catalog number CBA-0055 but was never intended to be distributed.
CC   Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.
DI   NCIt; C3476; Li-Fraumeni syndrome
DI   ORDO; Orphanet_524; Li-Fraumeni syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4415 ! IIICF/c
SX   Female
AG   30-40Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 16
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RX   PubMed=8108114;
RA   MacLean K., Rogan E.M., Whitaker N.J., Chang A.C.-M., Rowe P.B.,
RA   Dalla-Pozza L., Symonds G., Reddel R.R.;
RT   "In vitro transformation of Li-Fraumeni syndrome fibroblasts by SV40
RT   large T antigen mutants.";
RL   Oncogene 9:719-725(1994).
//
RX   PubMed=9175740; DOI=10.1093/hmg/6.6.921;
RA   Bryan T.M., Marusic L., Bacchetti S., Namba M., Reddel R.R.;
RT   "The telomere lengthening mechanism in telomerase-negative immortal
RT   human cells does not involve the telomerase RNA subunit.";
RL   Hum. Mol. Genet. 6:921-926(1997).
//
RX   PubMed=22829774; DOI=10.1371/journal.pgen.1002772; PMCID=PMC3400581;
RA   Lovejoy C.A., Li W.-D., Reisenweber S., Thongthip S., Bruno J.,
RA   de Lange T., De S., Petrini J.H.J., Sung P.A., Jasin M., Rosenbluh J.,
RA   Zwang Y., Weir B.A., Hatton C., Ivanova E.V., MacConaill L.E., Hanna M.,
RA   Hahn W.C., Lue N.F., Reddel R.R., Jiao Y.-C., Kinzler K.W.,
RA   Vogelstein B., Papadopoulos N., Meeker A.K.;
RG   ALT Starr Cancer Consortium;
RT   "Loss of ATRX, genome instability, and an altered DNA damage response
RT   are hallmarks of the alternative lengthening of telomeres pathway.";
RL   PLoS Genet. 8:E1002772-E1002772(2012).
//