ID   RWP-1
AC   CVCL_4373
SY   RWP 1; RWP1; Roger Williams Pancreatic-1
DR   EFO; EFO_0022417
DR   cancercelllines; CVCL_4373
DR   Cosmic; 710870
DR   Cosmic; 948739
DR   GEO; GSM244429
DR   Progenetix; CVCL_4373
DR   Wikidata; Q54951495
RX   PubMed=7083162;
RX   PubMed=8026879;
RX   PubMed=9665481;
RX   PubMed=11169959;
RX   PubMed=11787853;
RX   PubMed=12800145;
RX   PubMed=19077451;
RX   PubMed=22585861;
RX   PubMed=27067801;
WW   https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/RWP-1.html
WW   http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=RWP-1
CC   Doubling time: 45 hours (PubMed=7083162; PubMed=8026879); 23.6 +- 0.54 hours (PubMed=27067801).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg58Ter (c.172C>T) (p.Pro72Leu, c.215C>T); ClinVar=VCV000376310; Zygosity=Unspecified (PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=8026879; PubMed=11169959; PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=11169959; PubMed=11787853).
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C8294; Pancreatic adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   57Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 25
//
RX   PubMed=7083162;
RA   Dexter D.L., Matook G.M., Meitner P.A., Bogaars H.A., Jolly G.A.,
RA   Turner M.D., Calabresi P.;
RT   "Establishment and characterization of two human pancreatic cancer
RT   cell lines tumorigenic in athymic mice.";
RL   Cancer Res. 42:2705-2714(1982).
//
RX   PubMed=8026879; DOI=10.1002/ijc.2910580207;
RA   Berrozpe G., Schaeffer J., Peinado M.A., Real F.X., Perucho M.;
RT   "Comparative analysis of mutations in the p53 and K-ras genes in
RT   pancreatic cancer.";
RL   Int. J. Cancer 58:185-191(1994).
//
RX   PubMed=9665481; DOI=10.1016/S0002-9440(10)65561-7; PMCID=PMC1852940;
RA   Paciucci R., Vila M.R., Adell T., Diaz V.M., Tora M., Nakamura T.,
RA   Real F.X.;
RT   "Activation of the urokinase plasminogen activator/urokinase
RT   plasminogen activator receptor system and redistribution of E-cadherin
RT   are associated with hepatocyte growth factor-induced motility of
RT   pancreas tumor cells overexpressing Met.";
RL   Am. J. Pathol. 153:201-212(1998).
//
RX   PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C;
RA   Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M.,
RA   Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.;
RT   "Non-random chromosomal rearrangements in pancreatic cancer cell lines
RT   identified by spectral karyotyping.";
RL   Int. J. Cancer 91:350-358(2001).
//
RX   PubMed=11787853; DOI=10.1007/s004280100474;
RA   Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R.,
RA   Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H.,
RA   Lohr J.-M., Scarpa A.;
RT   "Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras,
RT   p53, p16 and DPC4/Smad4.";
RL   Virchows Arch. 439:798-802(2001).
//
RX   PubMed=12800145; DOI=10.1002/gcc.10218;
RA   Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B.,
RA   Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A.,
RA   Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D.,
RA   Edwards P.A.W., Chaffanet M.;
RT   "A recurrent chromosome translocation breakpoint in breast and
RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
//
RX   PubMed=19077451; DOI=10.1159/000178871;
RA   Harada T., Chelala C., Crnogorac-Jurcevic T., Lemoine N.R.;
RT   "Genome-wide analysis of pancreatic cancer using microarray-based
RT   techniques.";
RL   Pancreatology 9:13-24(2009).
//
RX   PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396;
RA   Marcotte R., Brown K.R., Suarez Saiz F.J., Sayad A., Karamboulas K.,
RA   Krzyzanowski P.M., Sircoulomb F., Medrano M., Fedyshyn Y., Koh J.L.-Y.,
RA   van Dyk D., Fedyshyn B., Luhova M., Brito G.C., Vizeacoumar F.J.,
RA   Vizeacoumar F.S., Datti A., Kasimer D., Buzina A., Mero P.,
RA   Misquitta C., Normand J., Haider M., Ketela T., Wrana J.L.,
RA   Rottapel R., Neel B.G., Moffat J.;
RT   "Essential gene profiles in breast, pancreatic, and ovarian cancer
RT   cells.";
RL   Cancer Discov. 2:172-189(2012).
//
RX   PubMed=27067801; DOI=10.1186/s12885-016-2297-y; PMCID=PMC4828819;
RA   Miura K., Kimura K., Amano R., Yamazoe S., Ohira G., Murata A.,
RA   Nishio K., Hasegawa T., Yashiro M., Nakata B., Ohira M., Hirakawa K.;
RT   "Establishment and characterization of new cell lines of anaplastic
RT   pancreatic cancer, which is a rare malignancy: OCUP-A1 and OCUP-A2.";
RL   BMC Cancer 16:268.1-268.13(2016).
//