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Cellosaurus OV-1063 (CVCL_4366)

[Text version]
Cell line name OV-1063
Synonyms Ov-1063; OV 1063; OV1063; 0V-1063
Accession CVCL_4366
Resource Identification Initiative To cite this cell line use: OV-1063 (RRID:CVCL_4366)
Comments Problematic cell line: Partially misidentified. The stock formerly distributed by ATCC and CCRID was misidentified and was actually DU145 (Cellosaurus=CVCL_0105). This is not the case of the original stock from Hadassah Medical Center.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00340.
Omics: Transcriptome analysis by serial analysis of gene expression (SAGE).
Miscellaneous: STR profile from personal communication of Granit A., Hadassah Medical Center, Jerusalem, Israel.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Glu40Ter (c.118G>T); Zygosity=Unspecified (PubMed=11565033).
  • Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Unspecified (PubMed=25846456).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Unspecified (PubMed=25846456).
Disease Ovarian cystadenocarcinoma (NCIt: C5228)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO11
D1S165614,15.3
D2S44110,14
D2S133817
D3S135816,17
D5S81811,12
D7S82010,14
D8S11799,14
D10S124816,17
D12S39123
D13S31712
D16S53910,13
D18S5117,20
D19S43313,16.2
D21S1131,32.2
D22S104516
FGA20
Penta D12,15
Penta E7,16
TH019.3
TPOX11
vWA15,17

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=2412195; DOI=10.1159/000226056
Horowitz A.T., Treves A.J., Voss R., Okon E., Fuks Z., Davidson L., Biran S.
A new human ovarian carcinoma cell line: establishment and analysis of tumor-associated markers.
Oncology 42:332-337(1985)

PubMed=9698466; DOI=10.1006/gyno.1998.5039
Maxwell G.L., Risinger J.I., Tong B., Shaw H., Barrett J.C., Berchuck A., Futreal P.A.
Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.
Gynecol. Oncol. 70:13-16(1998)

PubMed=11103784
Hough C.D., Sherman-Baust C.A., Pizer E.S., Montz F.J., Im D.D., Rosenshein N.B., Cho K.R., Riggins G.J., Morin P.J.
Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer.
Cancer Res. 60:6281-6287(2000)

PubMed=11565033; DOI=10.1038/35095068
Moberg K.H., Bell D.W., Wahrer D.C.R., Haber D.A., Hariharan I.K.
Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines.
Nature 413:311-316(2001)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=25846456; DOI=10.3892/ijo.2015.2951
Takenaka M., Saito M., Iwakawa R., Yanaihara N., Saito M., Kato M., Ichikawa H., Shibata T., Yokota J., Okamoto A., Kohno T.
Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.
Int. J. Oncol. 46:2389-2398(2015)

Cross-references
Cell line collections (Providers) ATCC; CRL-2183 - Discontinued
Cell line databases/resources cancercelllines; CVCL_4366
CCRID; 1101HUM-PUMC000361
Biological sample resources BioSample; SAMN03152024
BioSample; SAMN03472561
Chemistry resources ChEMBL-Cells; CHEMBL3308411
ChEMBL-Targets; CHEMBL614211
PubChem_Cell_line; CVCL_4366
Encyclopedic resources Wikidata; Q54936820
Polymorphism and mutation databases Cosmic; 844352
Cosmic; 849609
Cosmic; 897432
Cosmic; 948286
Cosmic; 1044238
Cosmic; 2582808
Cosmic; 2674700
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26