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Cellosaurus CHO-xrs-6 (CVCL_4340)

[Text version]
Cell line name CHO-xrs-6
Synonyms CHO-XrS6; CHO-XRS6; CHO XrS6; xrs-6; xrs 6; XrS6; XRS6; xrs6
Accession CVCL_4340
Resource Identification Initiative To cite this cell line use: CHO-xrs-6 (RRID:CVCL_4340)
Comments Characteristics: Sensitive to X-ray. Has a defect in double-strand break rejoining (PubMed=6513971).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0214 (CHO-K1)
Children:
CVCL_4341 (CHO-xrs-6-hamKu80)CVCL_5A41 (CHO-xrs-6C)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=6197643; DOI=10.1016/0167-8817(83)90026-3
Jeggo P.A., Kemp L.M.
X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents.
Mutat. Res. 112:313-327(1983)

PubMed=6513971; DOI=10.1016/0167-8817(84)90037-3
Kemp L.M., Sedgwick S.G., Jeggo P.A.
X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining.
Mutat. Res. 132:189-196(1984)

PubMed=3785270; DOI=10.1016/0167-8817(86)90025-8
Kemp L.M., Jeggo P.A.
Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line.
Mutat. Res. 166:255-263(1986)

PubMed=2564870; DOI=10.1080/09553008914550651
Denekamp J., Whitmore G.F., Jeggo P.A.
Biphasic survival curves for XRS radiosensitive cells: subpopulations or transient expression of repair competence?
Int. J. Radiat. Biol. 55:605-617(1989)

PubMed=8799130; DOI=10.1073/pnas.93.17.8929; PMCID=PMC38571
Liang F., Romanienko P.J., Weaver D.T., Jeggo P.A., Jasin M.
Chromosomal double-strand break repair in Ku80-deficient cells.
Proc. Natl. Acad. Sci. U.S.A. 93:8929-8933(1996)

PubMed=9032253; DOI=10.1128/mcb.17.3.1264; PMCID=PMC231851
Singleton B.K., Priestley A., Steingrimsdottir H., Gell D., Blunt T., Jackson S.P., Lehmann A.R., Jeggo P.A.
Molecular and biochemical characterization of xrs mutants defective in Ku80.
Mol. Cell. Biol. 17:1264-1273(1997)

Cross-references
Cell line collections (Providers) ECACC; 92052128
Cell line databases/resources CLO; CLO_0009692
CLDB; cl4784
Anatomy/cell type resources BTO; BTO_0004066
Chemistry resources ChEMBL-Cells; CHEMBL3307295
ChEMBL-Targets; CHEMBL614060
PubChem_Cell_line; CVCL_4340
Encyclopedic resources Wikidata; Q54813132
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number14