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Cellosaurus P1.HTR (CVCL_4265)

[Text version]
Cell line name P1.HTR
Synonyms P1.HTR1; P1.B5.4.8.12.16.2
Accession CVCL_4265
Resource Identification Initiative To cite this cell line use: P1.HTR (RRID:CVCL_4265)
Comments Characteristics: Highly transfectable (ECACC=87121104).
Selected for resistance to: ChEBI; CHEBI_472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Transformant: ChEBI; CHEBI_34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
Sequence variations
  • Mutation; MGI; MGI:96677; Kit; Simple; p.Asp818Tyr (c.2452G>T) (D814Y); Zygosity=Unspecified (from parent cell line).
Disease Mouse mast cell neoplasm (NCIt: C21632)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: DBA/2.
Hierarchy Parent: CVCL_F735 (P815-X2)
Children:
CVCL_C0DG (HTR.B7-1)CVCL_C0DK (HTR.B7-2)CVCL_C0DL (HTR.C)
CVCL_4266 (P1.HTR.TK-)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=3929396; DOI=10.1007/BF01534840
Van Pel A., De Plaen E., Boon T.
Selection of highly transfectable variant from mouse mastocytoma P815.
Somat. Cell Mol. Genet. 11:467-475(1985)

PubMed=8609411; DOI=10.4049/jimmunol.156.8.2909
Gajewski T.F., Fallarino F., Uyttenhove C., Boon T.
Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.
J. Immunol. 156:2909-2917(1996)

PubMed=9310829; DOI=10.1093/intimm/9.9.1259
Fallarino F., Ashikari A., Boon T., Gajewski T.F.
Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells.
Int. Immunol. 9:1259-1269(1997)

PubMed=18432777; DOI=10.1002/0471142735.im2004s43
Gajewski T.F., Markiewicz M.A., Uyttenhove C.
The P815 mastocytoma tumor model.
Curr. Protoc. Immunol. 43:20.4.1-20.4.18(2001)

Cross-references
Cell line collections (Providers) ECACC; 87121104
Cell line databases/resources CLO; CLO_0008289
CLDB; cl3803
Encyclopedic resources Wikidata; Q54937216
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number15