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Cellosaurus RBA-2 (CVCL_4031)

[Text version]
Cell line name RBA-2
Synonyms RBA2; Rat Brain Astrocyte-2
Accession CVCL_4031
Resource Identification Initiative To cite this cell line use: RBA-2 (RRID:CVCL_4031)
Comments Characteristics: Type-2 astrocyte. A2B5, GFAP and glutamine synthetase positive (PubMed=10386986).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Cell type: Astrocyte; CL=CL_0000127.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: JAR-2.
Hierarchy Parent: CVCL_0494 (RBA-1)
Sex of cell Sex unspecified
Age at sampling 3D
Category Spontaneously immortalized cell line
Publications

PubMed=10386986; DOI=10.1046/j.1471-4159.1999.0730334.x
Sun S.H., Lin L.-B., Hung A.C., Kuo J.-S.
ATP-stimulated Ca2+ influx and phospholipase D activities of a rat brain-derived type-2 astrocyte cell line, RBA-2, are mediated through P2X7 receptors.
J. Neurochem. 73:334-343(1999)

PubMed=11746779; DOI=10.1002/glia.10004
Wang C.-M., Chang Y.-Y., Kuo J.-S., Sun S.H.
Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism.
Glia 37:8-18(2002)

PubMed=15985361; DOI=10.1016/j.cellsig.2005.02.009
Hung A.C., Chu Y.-J., Lin Y.-H., Weng J.-Y., Chen H.B., Au Y.-C., Sun S.H.
Roles of protein kinase C in regulation of P2X7 receptor-mediated calcium signalling of cultured type-2 astrocyte cell line, RBA-2.
Cell. Signal. 17:1384-1396(2005)

PubMed=16178011; DOI=10.1002/jcb.205
Chen H.B., Chan Y.-T., Hung A.C., Tsai Y.-C., Sun S.H.
Elucidation of ATP-stimulated stress protein expression of RBA-2 type-2 astrocytes: ATP potentiate HSP60 and Cu/Zn SOD expression and stimulates pI shift of peroxiredoxin II.
J. Cell. Biochem. 97:314-326(2006)

PubMed=18067549; DOI=10.1111/j.1471-4159.2007.05119.x
Lo J.-C., Huang W.-C., Chou Y.-C., Tseng C.-H., Lee W.-L., Sun S.H.
Activation of P2X(7) receptors decreases glutamate uptake and glutamine synthetase activity in RBA-2 astrocytes via distinct mechanisms.
J. Neurochem. 105:151-164(2008)

Cross-references
Cell line collections (Providers) BCRC; 60584
Anatomy/cell type resources BTO; BTO_0002599
Encyclopedic resources Wikidata; Q54949328
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number14