ID   SCC-12B
AC   CVCL_4027
SY   SCC-12b; SCC 12B; SCC12b; SCC12B; SCC-12 clone B
DR   BTO; BTO:0002192
DR   cancercelllines; CVCL_4027
DR   Cosmic; 1608862
DR   IARC_TP53; 1910
DR   Wikidata; Q54952328
RX   PubMed=1574572;
RX   PubMed=8390283;
RX   PubMed=22006338;
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Leu; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val216Gly (c.647T>G); ClinVar=VCV000376671; Zygosity=Unspecified (PubMed=8390283).
CC   Derived from site: In situ; Face, skin; UBERON=UBERON_1000021.
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4026 ! SCC-12
SX   Male
AG   60Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 14
//
RX   PubMed=1574572; DOI=10.2307/3578273;
RA   Dunphy E.J., Beckett M.A., Thompson L.H., Weichselbaum R.R.;
RT   "Expression of the polymorphic human DNA repair gene XRCC1 does not
RT   correlate with radiosensitivity in the cells of human head and neck
RT   tumor cell lines.";
RL   Radiat. Res. 130:166-170(1992).
//
RX   PubMed=8390283; DOI=10.1038/bjc.1993.238; PMCID=PMC1968513;
RA   Burns J.E., Baird M.C., Clark L.J., Burns P.A., Edington K.G.,
RA   Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.;
RT   "Gene mutations and increased levels of p53 protein in human squamous
RT   cell carcinomas and their cell lines.";
RL   Br. J. Cancer 67:1274-1284(1993).
//
RX   PubMed=22006338; DOI=10.1073/pnas.1114669108; PMCID=PMC3203814;
RA   Wang N.J., Sanborn Z., Arnett K.L., Bayston L.J., Liao W., Proby C.M.,
RA   Leigh I.M., Collisson E.A., Gordon P.B., Jakkula L.R., Pennypacker S.,
RA   Zou Y., Sharma M., North J.P., Vemula S.S., Mauro T.M., Neuhaus I.M.,
RA   LeBoit P.E., Hur J.S., Park K., Huh N., Kwok P.-Y., Arron S.T.,
RA   Massion P.P., Bale A.E., Haussler D., Cleaver J.E., Gray J.W.,
RA   Spellman P.T., South A.P., Aster J.C., Blacklow S.C., Cho R.J.;
RT   "Loss-of-function mutations in Notch receptors in cutaneous and lung
RT   squamous cell carcinoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:17761-17766(2011).
//