ID   SK-RC-45
AC   CVCL_4016
SY   SK-RC 45; SK RC 45; SKRC-45; SKRC45; RCC 45; RCC45
DR   BTO; BTO:0003201
DR   Cosmic; 737189
DR   IARC_TP53; 26509
DR   Wikidata; Q54954591
RX   PubMed=2386958;
RX   PubMed=12670922;
RX   PubMed=15026329;
RX   PubMed=27993170;
WW   https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-rc-m-metastatic-human-renal-cell-carcinoma-rcc-cell-line-collection
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Doubling time: 48 hours (PubMed=2386958).
CC   Miscellaneous: STR profile and age/sex of donor from MSKCC antibody and bioresource core facility.
CC   Derived from site: Metastatic; Adrenal gland; UBERON=UBERON_0002369.
ST   Source(s): MSKCC
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 13
ST   D18S51: 15
ST   D19S433: 14,16
ST   D21S11: 27,28
ST   D2S1338: 17,23
ST   D3S1358: 15
ST   D5S818: 12
ST   D7S820: 12
ST   D8S1179: 12,14
ST   FGA: 22,23
ST   TH01: 6,8
ST   TPOX: 8
ST   vWA: 15,16
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_4022 ! SK-RC-44
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 20
//
RX   PubMed=2386958;
RA   Ebert T., Bander N.H., Finstad C.L., Ramsawak R.D., Old L.J.;
RT   "Establishment and characterization of human renal cancer and normal
RT   kidney cell lines.";
RL   Cancer Res. 50:5531-5536(1990).
//
RX   PubMed=12670922;
RA   Kudo D., Rayman P., Horton C., Cathcart M.K., Bukowski R.M.,
RA   Thornton M., Tannenbaum C.S., Finke J.H.;
RT   "Gangliosides expressed by the renal cell carcinoma cell line SK-RC-45
RT   are involved in tumor-induced apoptosis of T cells.";
RL   Cancer Res. 63:1676-1683(2003).
//
RX   PubMed=15026329; DOI=10.1158/0008-5472.CAN-03-1541;
RA   Gurova K.V., Hill J.E., Razorenova O.V., Chumakov P.M., Gudkov A.V.;
RT   "p53 pathway in renal cell carcinoma is repressed by a dominant
RT   mechanism.";
RL   Cancer Res. 64:1951-1958(2004).
//
RX   PubMed=27993170; DOI=10.1186/s12943-016-0565-8; PMCID=PMC5168717;
RA   Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C.,
RA   Czarnecka A.M.;
RT   "Choosing the right cell line for renal cell cancer research.";
RL   Mol. Cancer 15:83.1-83.15(2016).
//